A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? (Q36674481)

15 August 2017

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title

A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? (English)

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15 August 2017

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Katleen Dillen

1

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PubMed ID

17148000

15 August 2017

Wim Annaert

series ordinal

2

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PubMed ID

17148000

15 August 2017

language of work or name

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1 January 2006

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International Review of Cytology

15 August 2017

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15 August 2017

254

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15 August 2017

215-300

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

15 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins: molecular switches between proteolysis and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A cell biological perspective on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Interaction of Tau with Fe65 links tau to APP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Negative regulation of fibroblast motility by Ena/VASP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification and characterization of presenilin-independent Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease: one disorder, too many genes?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

SorLA signaling by regulated intramembrane proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The GGA proteins: adaptors on the move

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Anti-Abeta: The good, the bad, and the unforeseen

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Apical sorting of beta-secretase limits amyloid beta-peptide production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gamma-secretase complex assembly within the early secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Strategies for disease modification in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Processing of beta-secretase by furin and other members of the proprotein convertase family

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Membrane topology of gamma-secretase component PEN-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Selective loss of central cholinergic neurons in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Purification and characterization of the human gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Immunotherapy of Alzheimer's disease (AD): from murine models to anti-amyloid beta (Abeta) human monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Pick bodies in a family with presenilin-1 Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE1 interacts with nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Oligomerization of human presenilin-1 fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A secreted form of human ADAM9 has an alpha-secretase activity for APP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Prodomain processing of Asp1 (BACE2) is autocatalytic.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin mutations associated with fronto-temporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Tau pathology in Alzheimer disease and other tauopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The gamma-secretase complex: machinery for intramembrane proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Vaccines for Alzheimer's disease: how close are we?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APP processing and synaptic function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A full genome scan for late onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Down-regulation of endogenous amyloid precursor protein processing due to cellular aging

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The ins and outs of presenilin 1 membrane topology

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE is degraded via the lysosomal pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The non-amyloidogenic pathway: structure and function of alpha-secretases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gamma-secretase: proteasome of the membrane?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cholesterol homeostasis failure as a unifying cause of synaptic degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mena is required for neurulation and commissure formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A nine-transmembrane domain topology for presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins in memory, Alzheimer's disease, and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Association of neuronal calcium channels with modular adaptor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Metals and amyloid-beta in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Hide and run. Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Sialylation enhances the secretion of neurotoxic amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gleevec inhibits β-amyloid production but not Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Three-dimensional structure of the γ-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Topology of the C-terminal fragment of human presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A Xenopus homologue of the human β-amyloid precursor protein: Development regulation of its gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin attenuates receptor-mediated signaling and synaptic function.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease: the cholesterol connection

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1: more than just gamma-secretase.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The amyloid-beta precursor protein: integrating structure with biological function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Metal-protein attenuating compounds and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Metal and inflammatory targets for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Axonal transport defects: a common theme in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification and characterization of a novel human APH-1b splice variant lacking exon 4

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Human BACE forms dimers and colocalizes with APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Clearing the brain's amyloid cobwebs

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

PEN-2 enhances gamma-cleavage after presenilin heterodimer formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gamma-secretase activity is associated with a conformational change of nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease and Abeta toxicity: from top to bottom

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Homo- and heterodimerization of APP family members promotes intercellular adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Mesp2 initiates somite segmentation through the Notch signalling pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Three types of amyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Identification of the role of presenilins beyond Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Progress in the discovery of BACE inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Association of active gamma-secretase complex with lipid rafts.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Gamma-secretase activity is present in rafts but is not cholesterol-dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Beta-amyloid protein promotes neuritic branching in hippocampal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Intramembrane proteolysis: theme and variations.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Intracellular retention of caveolin 1 in presenilin-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

BACE2 functions as an alternative alpha-secretase in cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

A dominant role for FE65 (APBB1) in nuclear signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilin-mediated modulation of capacitative calcium entry

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Alzheimer's disease: the two-hit hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2806%2954005-7

7 January 2021

10.1016/S0074-7696(06)54005-7

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17148000