Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1). (Q44538958)

3 December 2017

Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1). (English)

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3 December 2017

1

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3 December 2017

2

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3 December 2017

Valérie Bourdages

3

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3 December 2017

Chantal Godin

4

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3 December 2017

Mélissa Ferland

5

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3 December 2017

Madeleine Carreau

6

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3 December 2017

Georges Lévesque

7

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3 December 2017

1 August 2003

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3 December 2017

Neurobiology of Disease

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3 December 2017

13

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3 December 2017

3

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3 December 2017

238-245

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Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

3 December 2017

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https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

BACE1 interacts with nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

The unfolded protein response and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Presenilin-1 mutations in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

The role of beta-amyloid in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Cellular mechanisms of beta-amyloid production and secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900035-4

7 January 2021

10.1016/S0969-9961(03)00035-4

Identifiers

DOI

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3 December 2017

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