Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation (Q40601680)

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scientific article published on 6 January 2004

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English	Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation	scientific article published on 6 January 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation (English)

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Europe PubMed Central

PubMed publication ID

21 September 2017

cell differentiation

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based on heuristic

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author name string

Gwendolyn T Wong

1

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21 September 2017

Denise Manfra

2

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21 September 2017

Frederique M Poulet

3

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21 September 2017

Qi Zhang

4

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21 September 2017

Hubert Josien

5

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21 September 2017

Thomas Bara

6

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21 September 2017

Laura Engstrom

7

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21 September 2017

Maria Pinzon-Ortiz

8

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21 September 2017

Jay S Fine

9

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21 September 2017

Hu-Jung J Lee

10

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21 September 2017

Lili Zhang

11

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21 September 2017

Guy A Higgins

12

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21 September 2017

Eric M Parker

13

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21 September 2017

language of work or name

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publication date

6 January 2004

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21 September 2017

Journal of Biological Chemistry

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21 September 2017

279

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21 September 2017

13

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21 September 2017

12876-12882

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21 September 2017

Deaths attributable to Alzheimer's disease in the United States.

1 reference

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The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Correlations of synaptic and pathological markers with cognition of the elderly

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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21 January 2018

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

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21 January 2018

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

LIN-12/Notch signaling: lessons from worms and flies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

An invitation to T and more: notch signaling in lymphopoiesis

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21 January 2018

Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome

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21 January 2018

Presenilin-dependent gamma-secretase activity modulates thymocyte development

1 reference

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21 January 2018

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

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21 January 2018

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311652200

21 January 2018

Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditions

1 reference

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21 January 2018

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

1 reference

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21 January 2018

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

1 reference

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21 January 2018

Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

1 reference

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21 January 2018

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

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Control of endodermal endocrine development by Hes-1

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Thymic regeneration: teaching an old immune system new tricks

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M311652200

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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