The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling (Q24531382)

2

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Meir H Scheinfeld

object named as

Meir H Scheinfeld

3

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Peter Lopez

object named as

Peter A Lopez

5

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Luciano D'Adamio

object named as

Luciano D'Adamio

9

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author name string

Roberta Roncarati

1

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Bridget E Berechid

4

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Olimpia Meucci

6

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Jane C McGlade

7

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Pasko Rakic

Proceedings of the National Academy of Sciences of the United States of America

8

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language of work or name

English

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publication date

14 May 2002

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published in

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volume

99

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issue

10

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page(s)

7102-7

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cites work

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Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

24 March 2017

1 reference

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SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

24 March 2017

1 reference

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Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

24 March 2017

1 reference

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Notch signaling: cell fate control and signal integration in development

24 March 2017

1 reference

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Alzheimer's disease: genes, proteins, and therapy

24 March 2017

1 reference

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

24 March 2017

1 reference

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

24 March 2017

1 reference

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

24 March 2017

1 reference

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The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

24 March 2017

1 reference

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Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

24 March 2017

1 reference

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Identification and characterization of presenilin-independent Notch signaling

24 March 2017

1 reference

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Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

27 September 2017

1 reference

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

27 September 2017

1 reference

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A portrait of Alzheimer secretases--new features and familiar faces

27 September 2017

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Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

27 September 2017

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Nuclear Notch1 signaling and the regulation of dendritic development

27 September 2017

1 reference

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Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

27 September 2017

1 reference

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The presenilins in Alzheimer's disease--proteolysis holds the key.

27 September 2017

1 reference

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27 September 2017

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Processing of the notch ligand delta by the metalloprotease Kuzbanian

27 September 2017

1 reference

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Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.

27 September 2017

1 reference

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

27 September 2017

1 reference

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

27 September 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.102192599

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.102192599

Notch1 inhibits neurite outgrowth in postmitotic primary neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.102192599

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.102192599

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.102192599

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.102192599

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124535

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12011466

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12011466

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.102192599

1 reference

1656342

ADS bibcode

2002PNAS...99.7102R

0 references

1656342

1 reference

1 reference

1 reference