Down-regulation of endogenous amyloid precursor protein processing due to cellular aging (Q40348451)

19 September 2017

Down-regulation of endogenous amyloid precursor protein processing due to cellular aging (English)

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19 September 2017

Andreas Kern

1

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19 September 2017

Birgit Roempp

2

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19 September 2017

Kai Prager

3

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19 September 2017

Jochen Walter

4

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19 September 2017

Christian Behl

5

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19 September 2017

language of work or name

English

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publication date

22 November 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

281

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19 September 2017

5

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19 September 2017

2405-2413

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Model systems, lipid rafts, and cell membranes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M505625200

Lipid rafts-protein association and the regulation of protein activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Robert Feulgen Lecture 1997. Lipid microdomains and membrane trafficking in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Cholesterol and Alzheimer's disease: is there a link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Neuronal membrane cholesterol loss enhances amyloid peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

The serial cultivation of human diploid cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

21 January 2018

Coming of age in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Molecular markers of senescence in fibroblast-like cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

High cholesterol affects platelet APP processing in controls and in AD patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Cellular aging-dependent decrease in cholesterol in membrane microdomains of human diploid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Replicative senescence: a critical review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

N-linked glycosylation of beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Intracellular retention of caveolin 1 in presenilin-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Increased caveolin-1 expression in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Dietary restriction counteracts age-related changes in cholesterol metabolism in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505625200

21 January 2018

Identifiers

DOI

10.1074/JBC.M505625200

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19 September 2017

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