Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations (Q24301868)

GOA release 2020-03-11

8

Bart De Strooper

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Lutgarde Serneels

object named as

Lutgarde Serneels

7

1 reference

ORCID Public Data File 2021

author name string

Huiping Tu

1

0 references

Omar Nelson

2

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Arseny Bezprozvanny

3

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Zhengnan Wang

4

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Sheu-Fen Lee

5

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Yi-Heng Hao

6

0 references

Gang Yu

9

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Ilya Bezprozvanny

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

10

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language of work or name

English

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publication date

8 September 2006

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published in

Cell

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volume

126

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page(s)

981-93

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issue

5

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cites work

1 reference

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Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

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A nine-transmembrane domain topology for presenilin 1

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

19 March 2017

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

19 March 2017

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Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

19 March 2017

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

19 March 2017

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Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals

7 April 2017

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Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

27 September 2017

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Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region

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The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations

27 September 2017

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27 September 2017

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Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

27 September 2017

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Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators.

27 September 2017

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Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores

27 September 2017

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

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27 September 2017

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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

30 May 2018

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

30 May 2018

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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

30 May 2018

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Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.

30 May 2018

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Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview.

30 May 2018

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Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

30 May 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

29 November 2018

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Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores

29 November 2018

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Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

29 November 2018

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Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1.

29 November 2018

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Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

29 November 2018

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Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons

29 November 2018

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Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

29 November 2018

1 reference

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Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241869

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241869

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16959576

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Presenilin-mediated modulation of capacitative calcium entry

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16959576

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2006.06.059

1 reference

812079

812079

1 reference

1 reference

1 reference