Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. (Q40481988)

20 September 2017

Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. (English)

1 reference

20 September 2017

Thomas J Nelson

1

1 reference

PubMed ID

15591071

20 September 2017

Daniel L Alkon

series ordinal

2

1 reference

PubMed ID

15591071

20 September 2017

language of work or name

English

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publication date

8 December 2004

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

7377-7387

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20 September 2017

8

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Cholesterol and APOE genotype interact to influence Alzheimer disease progression

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Alzheimer's disease: the cholesterol connection

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

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Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels

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Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

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APP gene family. Alternative splicing generates functionally related isoforms.

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Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of amyloid-beta peptide

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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Redox-active metals, oxidative stress, and Alzheimer's disease pathology

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Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

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Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

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Sterol metabolism. XXV. Cholesterol oxidation by singlet molecular oxygen

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Hippocampal protein-protein interactions in spatial memory.

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Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1.

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A continuous fluorimetric assay for tumor necrosis factor-alpha converting enzyme

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Differential expression of cholesterol hydroxylases in Alzheimer's disease

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Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle

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Oxysterols as indices of oxidative stress in man after paraquat ingestion

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On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.

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Metabolism of 4 beta -hydroxycholesterol in humans.

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Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation

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Characterization of 2',7'-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide.

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Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols

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Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol

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Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death.

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Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells

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Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes

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Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

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Probing the origins of increased activity of the E22Q "Dutch" mutant Alzheimer's beta-amyloid peptide

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Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence

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Metabolite-initiated protein misfolding may trigger Alzheimer's disease

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7alpha-Hydroperoxycholesterol causes CNS neuronal cell death

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Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status.

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Cellular sterol accumulation stimulated by cholesterol 5 beta,6 beta-epoxide in J774 macrophages

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Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation

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Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

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Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

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Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro

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Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity

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22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide

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The receptor-bound N-terminal ectodomain of the amyloid precursor protein is associated with membrane rafts.

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Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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21 January 2018

Identifiers

DOI

10.1074/JBC.M409071200

1 reference

20 September 2017

1 reference

PubMed ID

15591071