Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice (Q37137534)

18 August 2017

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice (English)

1 reference

18 August 2017

Matthew J Chiocco

1

1 reference

18 August 2017

Laura Shapiro Kulnane

2

1 reference

18 August 2017

Linda Younkin

3

1 reference

18 August 2017

Steve Younkin

4

1 reference

18 August 2017

Geneviève Evin

5

1 reference

18 August 2017

Bruce T Lamb

6

1 reference

18 August 2017

language of work or name

English

0 references

publication date

27 September 2004

1 reference

Journal of Biological Chemistry

18 August 2017

8

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

18 August 2017

279

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18 August 2017

52535-52542

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18 August 2017

50

1 reference

Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Purification and cloning of amyloid precursor protein beta-secretase from human brain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Translating cell biology into therapeutic advances in Alzheimer's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

A simple salting out procedure for extracting DNA from human nucleated cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Frequency of stages of Alzheimer-related lesions in different age categories

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Presence of both odor identification and detection deficits in Alzheimer's disease.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

The nature and course of olfactory deficits in Alzheimer's disease.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

27 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Association studies using novel polymorphisms in BACE1 and BACE2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Specific BACE1 genotypes provide additional risk for late‐onset alzheimer disease in APOE ε4 carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Alterations in beta-amyloid production and deposition in brain regions of two transgenic models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Early olfactory involvement in Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659546

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

3 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409680200

Olfactory identification deficits in relatives of Alzheimer's disease patients

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15452128

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M409680200

1 reference

18 August 2017

1 reference

18 August 2017

1 reference