Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. (Q46715173)

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scientific article published in September 2005

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English	Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.	scientific article published in September 2005

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scholarly article

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7 January 2020

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice (English)

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7 January 2020

Alzheimer's disease

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John Anthony Hardy

11

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John Hardy

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24 December 2017

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Jared Ehrhart

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7 January 2020

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Jun Tan

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7 January 2020

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Takashi Mori

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7 January 2020

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Terrence Town

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7 January 2020

Kavon Rezai-Zadeh

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Kavon Rezai-Zadeh

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7 January 2020

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Doug Shytle

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7 January 2020

Nan Sun

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7 January 2020

Huayan Hou

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7 January 2020

Deborah Jeanniton

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Kirk Townsend

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7 January 2020

Jin Zeng

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7 January 2020

David Morgan

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John Hardy

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1 September 2005

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7 January 2020

Journal of Neuroscience

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38

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7 January 2020

8807-8814

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7 January 2020

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Cellular mechanisms of beta-amyloid production and secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Cancer chemoprevention by tea polyphenols.

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12 December 2020

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Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

1 reference

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Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation

1 reference

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12 December 2020

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Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression

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12 December 2020

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Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease

1 reference

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Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

1 reference

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Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

1 reference

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Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

1 reference

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12 December 2020

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The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease

1 reference

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12 December 2020

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Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic β-cell damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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A single ascending dose study of epigallocatechin gallate in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576.

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https://pubmed.ncbi.nlm.nih.gov/16177050

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Tea and Cancer Prevention: Studies in Animals and Humans

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https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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Green tea catechins as a BACE1 (β-Secretase) inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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ADAMs family members as amyloid precursor protein alpha-secretases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

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inferred from PubMed ID database lookup

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.

1 reference

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12 December 2020

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Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice

1 reference

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Green tea polyphenols and cancer chemoprevention: multiple mechanisms and endpoints for phase II trials.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16177050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1521-05.2005

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7 January 2020

1 reference

Europe PubMed Central

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7 January 2020

1 reference

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7 January 2020

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