Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex (Q36381474)

13 August 2017

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex (English)

1 reference

13 August 2017

Yue Hu

1

1 reference

PMCID

2199374

13 August 2017

Mark E Fortini

series ordinal

2

1 reference

PMCID

2199374

13 August 2017

language of work or name

English

0 references

publication date

1 May 2003

1 reference

13 August 2017

6

1 reference

based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

1 reference

13 August 2017

161

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13 August 2017

685-690

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13 August 2017

4

1 reference

The role of presenilin cofactors in the gamma-secretase complex

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

A common enzyme connects notch signaling and Alzheimer's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Presenilin is required for activity and nuclear access of Notch in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Synaptic transmission persists in synaptotagmin mutants of Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Nicastrin binds to membrane-tethered Notch

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Characterization of Drosophila Presenilin and its colocalization with Notch during development.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199374

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

28 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304014

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304014

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304014

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304014

21 January 2018

Identifiers

DOI

10.1083/JCB.200304014

1 reference

13 August 2017

1 reference

13 August 2017

1 reference

PMCID

2199374