Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores (Q24546956)

22 June 2017

title

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores (English)

1 reference

22 June 2017

Patrick C Fraering

2

Patrick C

Fraering

1 reference

19 October 2023

Vlado K Lazarov

1

Vlado K

Lazarov

1 reference

19 October 2023

5

Dennis J Selkoe

Dennis J

Selkoe

1 reference

22 June 2017

Wenjuan Ye

3

Wenjuan

Ye

1 reference

22 June 2017

Michael S Wolfe

series ordinal

4

author given names

Michael S

author last names

Wolfe

1 reference

22 June 2017

Huilin Li

series ordinal

6

author given names

Huilin

author last names

Li

1 reference

22 June 2017

language of work or name

English

0 references

publication date

24 April 2006

1 reference

22 June 2017

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

22 June 2017

volume

103

1 reference

22 June 2017

issue

18

1 reference

22 June 2017

page(s)

6889-6894

1 reference

Purification and characterization of the human gamma-secretase complex

22 June 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

X-ray structure of a protein-conducting channel

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

UCSF Chimera--a visualization system for exploratory research and analysis

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

EMAN: semiautomated software for high-resolution single-particle reconstructions

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

A nine-transmembrane domain topology for presenilin 1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Molecular Architecture of the Multiprotein Splicing Factor SF3b

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Proteasomes and their kin: proteases in the machine age

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

The 26S proteasome: a molecular machine designed for controlled proteolysis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

The proteasome: paradigm of a self-compartmentalizing protease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Games played by rogue proteins in prion disorders and Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

The role of presenilin cofactors in the gamma-secretase complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Novel structures of plant lectins and their complexes with carbohydrates.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

27 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

27 September 2017

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Domain structure of separase and its binding to securin as determined by EM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0602321103

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458989

Three-dimensional structure of the human TFIID-IIA-IIB complex

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16636269

12 December 2020

inferred from PubMed ID database lookup

Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16636269

12 December 2020

inferred from PubMed ID database lookup

Elucidation of the stator organization in the V-ATPase of Neurospora crassa

1 reference

https://pubmed.ncbi.nlm.nih.gov/16636269

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0602321103

1 reference

release_rcrr6xdnl5dkvjqdqhqwj5dfzu

22 June 2017

0 references

0 references

PMC publication ID

1458989

0 references

1 reference