Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. (Q40485801)

20 September 2017

Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

6

Bart De Strooper

1 reference

20 September 2017

Ira Espuny Camacho

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

Lutgarde Serneels

2

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12 May 2020

Kurt Spittaels

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

Pascal Merchiers

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

Diana Dominguez

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

Bart De Strooper

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

language of work or name

English

0 references

publication date

1 December 2004

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20 September 2017

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

volume

24

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12 May 2020

page(s)

10908-10917

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12 May 2020

issue

48

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

12 May 2020

cites work

1 reference

12 December 2020

Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs).

1 reference

12 December 2020

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

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12 December 2020

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

1 reference

12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

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12 December 2020

The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte/macrophage function.

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

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12 December 2020

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

The PPARs: from orphan receptors to drug discovery

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12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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12 December 2020

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo

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12 December 2020

The hormone resistin links obesity to diabetes

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12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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12 December 2020

Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1.

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12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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12 December 2020

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

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12 December 2020

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

12 December 2020

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

1 reference

12 December 2020

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma augments tumor necrosis factor family-induced apoptosis in hepatocellular carcinoma

1 reference

12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 December 2020

Arrayed adenoviral expression libraries for functional screening

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12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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12 December 2020

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

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12 December 2020

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

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12 December 2020

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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12 December 2020

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

12 December 2020

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

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12 December 2020

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

1 reference

12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

12 December 2020

Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.

1 reference

12 December 2020

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1 reference

12 December 2020

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease.

1 reference

12 December 2020

Signalling downstream of activated mammalian Notch

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12 December 2020

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha

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12 December 2020

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence

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12 December 2020

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease.

1 reference

12 December 2020

The peroxisome proliferator-activated receptor interacts with the retinoid X receptor in vivo

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12 December 2020

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

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12 December 2020

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation

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12 December 2020

Alzheimer's disease families with amyloid precursor protein mutations.

1 reference

12 December 2020

Microglia in degenerative neurological disease.

1 reference

12 December 2020

Low frequency of the APP 670/671 mutation in familial Alzheimer's disease in Sweden

1 reference

12 December 2020

The nuclear receptor superfamily: the second decade

1 reference

12 December 2020

Anti-inflammatory drugs in the fight against Alzheimer's disease

1 reference

12 December 2020

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

12 December 2020

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

1 reference

12 December 2020

Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology

1 reference

12 December 2020

Risk of Alzheimer's disease and duration of NSAID use.

1 reference

12 December 2020

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1 reference

12 December 2020

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

1 reference

12 December 2020

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.

1 reference

12 December 2020

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization

1 reference

12 December 2020

Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1.

1 reference

12 December 2020

Orphan nuclear receptors--new ligands and new possibilities.

1 reference

12 December 2020

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains.

1 reference

12 December 2020

10.1523/JNEUROSCI.3987-04.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730204&resulttype=core&format=json

12 May 2020

1 reference