Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. (Q40360520)

19 September 2017

title

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. (English)

1 reference

19 September 2017

main subject

transmembrane protein

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author name string

Seong-Hun Kim

series ordinal

1

1 reference

19 September 2017

Sangram S Sisodia

series ordinal

2

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19 September 2017

language of work or name

English

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publication date

18 October 2005

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

280

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19 September 2017

issue

51

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19 September 2017

page(s)

41953-41966

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

19 September 2017

cites work

1 reference

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Reconstitution of gamma-secretase activity

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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.

21 January 2018

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

21 January 2018

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Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

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Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

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A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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Membrane topology of gamma-secretase component PEN-2.

21 January 2018

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Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

21 January 2018

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The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

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A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

21 January 2018

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The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

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Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

21 January 2018

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A nine-transmembrane domain topology for presenilin 1

21 January 2018

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

21 January 2018

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Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

21 January 2018

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21 January 2018

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Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

21 January 2018

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Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

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A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

21 January 2018

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

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Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

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Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509070200

21 January 2018

Identifiers

DOI

10.1074/JBC.M509070200

1 reference

19 September 2017

1 reference