BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease (Q44722202)

5 December 2017

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease (English)

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5 December 2017

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8

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5 December 2017

5

Steven G Younkin

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5 December 2017

3

Linda H Younkin

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5 December 2017

Masuo Ohno

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5 December 2017

Evgeny A Sametsky

2

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5 December 2017

Holly Oakley

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5 December 2017

Martin Citron

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5 December 2017

Robert Vassar

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5 December 2017

language of work or name

English

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publication date

1 January 2004

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27-33

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Learning and memory in transgenic mice modeling Alzheimer's disease

5 December 2017

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7 January 2021

Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link?

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7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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7 January 2021

Alzheimer's disease: treatments in discovery and development

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7 January 2021

Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.

1 reference

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7 January 2021

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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7 January 2021

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

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7 January 2021

Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

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7 January 2021

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

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7 January 2021

Immunotherapy for Alzheimer's disease

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

The neuroendocrine basis of social recognition

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7 January 2021

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

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7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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7 January 2021

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

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7 January 2021

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

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7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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7 January 2021

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

Amyloid beta peptide impaired carbachol but not glutamate-mediated phosphoinositide pathways in cultured rat cortical neurons.

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7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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7 January 2021

Transgenic mouse models of Alzheimer's disease

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7 January 2021

Human β-Secretase (BACE) and BACE Inhibitors

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7 January 2021

APP processing and synaptic function

1 reference

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7 January 2021

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900810-9

7 January 2021

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900810-9

7 January 2021

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

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7 January 2021

Long-term memory underlying hippocampus-dependent social recognition in mice

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7 January 2021

The neurobiological basis of spontaneous alternation

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7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

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7 January 2021

BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse

1 reference

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7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

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7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900810-9

7 January 2021

BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

1 reference

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7 January 2021

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

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7 January 2021

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

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7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

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7 January 2021

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

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7 January 2021

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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7 January 2021

Long-lasting cholinergic modulation underlies rule learning in rats.

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7 January 2021

Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing

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7 January 2021

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

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7 January 2021

Alzheimer's disease is a synaptic failure

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7 January 2021

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease.

1 reference

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7 January 2021

Study of Memapsin 2 (β-Secretase) and Strategy of Inhibitor Design

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7 January 2021

Amyloid beta-peptide induces cholinergic dysfunction and cognitive deficits: a minireview

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7 January 2021

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

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7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

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7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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7 January 2021

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

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7 January 2021

Cholinergic modulation of a decrement in social investigation following repeated contacts between mice

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7 January 2021

Therapeutic strategies for Alzheimer's disease

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7 January 2021

Genetically engineered mouse models of neurodegenerative diseases

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900810-9

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

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7 January 2021

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900810-9

7 January 2021

Impaired Modulation of GABAergic Transmission by Muscarinic Receptors in a Mouse Transgenic Model of Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900810-9

7 January 2021

10.1016/S0896-6273(03)00810-9

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5 December 2017

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