Eukaryotic DNA damage checkpoint activation in response to double-strand breaks (Q37956184)

25 August 2017

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks (English)

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25 August 2017

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Muriel Grenon

3

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Noel F. Lowndes

object named as

Noel Francis Lowndes

series ordinal

2

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author name string

Karen Finn

series ordinal

1

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25 August 2017

15 November 2011

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Cellular and Molecular Life Sciences

25 August 2017

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25 August 2017

69

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25 August 2017

9

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25 August 2017

1447-1473

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https://scigraph.springernature.com/pub.10.1007/s00018-011-0875-3

25 August 2017

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Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

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21 January 2018

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An overview of Cdk1-controlled targets and processes

21 January 2018

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21 January 2018

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21 January 2018

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RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae

21 January 2018

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The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment

21 January 2018

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Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

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Surviving the breakup: the DNA damage checkpoint.

21 January 2018

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Common mechanisms of PIKK regulation

21 January 2018

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Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation

21 January 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

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Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase

21 January 2018

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

21 January 2018

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Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

21 January 2018

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Regulation of DNA repair throughout the cell cycle

21 January 2018

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Beyond ATM: the protein kinase landscape of the DNA damage response

21 January 2018

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

21 January 2018

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Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid

21 January 2018

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Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae

21 January 2018

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Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

21 January 2018

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Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

21 January 2018

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The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

21 January 2018

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Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

21 January 2018

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

21 January 2018

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

21 January 2018

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The role of DNA dependent protein kinase in synapsis of DNA ends.

21 January 2018

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Coping with DNA double strand breaks

21 January 2018

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Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

21 January 2018

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

21 January 2018

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The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

21 January 2018

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Differential regulation of the cellular response to DNA double-strand breaks in G1.

21 January 2018

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

21 January 2018

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The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle

21 January 2018

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CDK targets Sae2 to control DNA-end resection and homologous recombination

21 January 2018

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of homologous recombination in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MRN and the race to the break

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The yeast Xrs2 complex functions in S phase checkpoint regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Activation of protein kinase Tel1 through recognition of protein-bound DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chromatin dynamics and the preservation of genetic information

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chromatin modulation and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Epigenetic modifications in double-strand break DNA damage signaling and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chromatin dynamics and the repair of DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Control of sister chromatid recombination by histone H2AX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Crosstalk between histone modifications during the DNA damage response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chromatin dynamics coupled to DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Activation of the cellular DNA damage response in the absence of DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The ubiquitous role of ubiquitin in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Multiplicity of DNA end resection machineries in chromosome break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mechanisms and regulation of DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Human CtIP promotes DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Yeast checkpoint genes in DNA damage processing: implications for repair and arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Destroying the ring: Freeing DNA from Ku with ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATR and ATRIP: partners in checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Crystal structure of the human rad9-hus1-rad1 clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A novel Rad24 checkpoint protein complex closely related to replication factor C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Probing ATR activation with model DNA templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

TopBP1 activates the ATR-ATRIP complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Dpb11 activates the Mec1-Ddc2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Dot1p modulates silencing in yeast by methylation of the nucleosome core

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of checkpoint kinases through dynamic interaction with Crb2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A multidimensional chromatography technology for in-depth phosphoproteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tag.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

53BP1, a mediator of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

53BP1 promotes ATM activity through direct interactions with the MRN complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A quantitative atlas of mitotic phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation dynamics during early differentiation of human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Profiling of UV-induced ATM/ATR signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Identification of CDK2 substrates in human cell lysates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The FHA domain is a modular phosphopeptide recognition motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A domain of Rad9 specifically required for activation of Chk1 in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATRMec1 phosphorylation-independent activation of Chk1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mrc1 transduces signals of DNA replication stress to activate Rad53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rad53 checkpoint kinase phosphorylation site preference identified in the Swi6 protein of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Toward maintaining the genome: DNA damage and replication checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The S-phase checkpoint: targeting the replication fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA replication as a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A central role for DNA replication forks in checkpoint activation and response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The DNA replication checkpoint response stabilizes stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A role for DNA primase in coupling DNA replication to DNA damage response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Damage-induced phosphorylation of Sld3 is important to block late origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DUN1 encodes a protein kinase that controls the DNA damage response in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATR: an essential regulator of genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The multiple facets of the intra-S checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Human claspin is required for replication checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Coupling of human circadian and cell cycles by the timeless protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The metaphase-to-anaphase transition: avoiding a mid-life crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

DNA damage checkpoints inhibit mitotic exit by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5p

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MicroRNA regulation by RNA-binding proteins and its implications for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Impaired microRNA processing enhances cellular transformation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

21 January 2018

12 December 2020

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0875-3

Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition

21 January 2018

1 reference

12 December 2020

mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15.

1 reference

12 December 2020

Regulation of DNA-replication origins during cell-cycle progression

1 reference

12 December 2020

Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination

1 reference

12 December 2020

DNA end-joining: from yeast to man

1 reference

12 December 2020

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

1 reference

12 December 2020

MEC1-dependent phosphorylation of Rad9p in response to DNA damage

1 reference

12 December 2020

RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.

1 reference

12 December 2020

Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage

1 reference

12 December 2020

14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks

1 reference

12 December 2020

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

1 reference

12 December 2020

Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae

1 reference

12 December 2020

Knockdown of Dicer in MCF-7 human breast carcinoma cells results in G1 arrest and increased sensitivity to cisplatin.

1 reference

12 December 2020

Yeast Ku as a regulator of chromosomal DNA end structure

1 reference

12 December 2020

Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε

1 reference

12 December 2020

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

1 reference

12 December 2020

Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants

1 reference

12 December 2020

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

1 reference

12 December 2020

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites

1 reference

12 December 2020

Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents

1 reference

12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

12 December 2020

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

1 reference

12 December 2020

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms

1 reference

12 December 2020

Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation.

1 reference

12 December 2020

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner

1 reference

12 December 2020

Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division

1 reference

12 December 2020

FHA domain-mediated DNA checkpoint regulation of Rad53

1 reference

12 December 2020

DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae

1 reference

12 December 2020

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

1 reference

12 December 2020

The Rad50 hook domain is a critical determinant of Mre11 complex functions

1 reference

12 December 2020

Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres

1 reference

12 December 2020

The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements

1 reference

12 December 2020

A DNA damage response pathway controlled by Tel1 and the Mre11 complex

1 reference

12 December 2020

ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage

1 reference

12 December 2020

Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae

1 reference

12 December 2020

Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination

1 reference

12 December 2020

Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae

1 reference

12 December 2020

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

1 reference

12 December 2020

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

1 reference

12 December 2020

Cyclins and the wiring of the yeast cell cycle

1 reference

12 December 2020

The G(2) DNA damage checkpoint targets both Wee1 and Cdc25.

1 reference

12 December 2020

MicroRNAs, the DNA damage response and cancer

1 reference

12 December 2020

DNA-dependent protein kinase and related proteins.

1 reference

12 December 2020

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates

1 reference

12 December 2020

Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway

1 reference

12 December 2020

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms

1 reference

12 December 2020

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

1 reference

12 December 2020

Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity

1 reference

12 December 2020

DNA end resection--unraveling the tail

1 reference

12 December 2020

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1 reference

12 December 2020

Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair.

1 reference

12 December 2020

10.1007/S00018-011-0875-3

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

22083606