A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase (Q22008669)

cellular response to DNA damage stimulus

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

A Blasina

1

A

Blasina

1 reference

7 February 2023

I V de Weyer

2

I V

de Weyer

1 reference

7 February 2023

M C Laus

3

M C

Laus

1 reference

7 February 2023

W H Luyten

4

W H

Luyten

1 reference

7 February 2023

A E Parker

5

A E

Parker

1 reference

7 February 2023

C H McGowan

6

C H

Checkpoints: controls that ensure the order of cell cycle events

McGowan

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7 February 2023

language of work or name

English

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publication date

14 January 1999

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published in

Current Biology

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volume

9

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issue

1

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page(s)

1-10

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

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Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

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Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

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Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2

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Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

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Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition

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A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.

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p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53.

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

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Interaction between ATM protein and c-Abl in response to DNA damage

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Dual roles of ATM in the cellular response to radiation and in cell growth control.

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A kinase from fission yeast responsible for blocking mitosis in S phase.

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Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

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The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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Replication checkpoint enforced by kinases Cds1 and Chk1.

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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

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A DNA damage checkpoint meets the cell cycle engine

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The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts

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Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

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14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast.

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Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways

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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

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S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

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DNA-replication checkpoint control at the Drosophila midblastula transition

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The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

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Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors

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Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

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