MRN and the race to the break (Q37622790)

21 August 2017

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title

MRN and the race to the break (English)

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21 August 2017

Muriel Grenon

3

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Noel F. Lowndes

object named as

Noel F Lowndes

series ordinal

2

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author name string

Agnieszka Rupnik

series ordinal

1

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21 August 2017

28 October 2009

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21 August 2017

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21 August 2017

119

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21 August 2017

2

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21 August 2017

115-135

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https://scigraph.springernature.com/pub.10.1007/s00412-009-0242-4

21 August 2017

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cites work

Methylation of MRE11 regulates its nuclear compartmentalization

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00412-009-0242-4

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

21 January 2018

1 reference

12 December 2020

Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres

1 reference

12 December 2020

Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination

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12 December 2020

Structure and function of the phosphothreonine-specific FHA domain.

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12 December 2020

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

1 reference

12 December 2020

Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

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12 December 2020

The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

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12 December 2020

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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12 December 2020

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

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12 December 2020

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

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12 December 2020

The multiple roles of the Mre11 complex for meiotic recombination

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12 December 2020

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

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12 December 2020

Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining

1 reference

12 December 2020

XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination

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12 December 2020

Homologous recombination in DNA repair and DNA damage tolerance

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12 December 2020

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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12 December 2020

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

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12 December 2020

Multiplicity of DNA end resection machineries in chromosome break repair

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12 December 2020

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

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12 December 2020

Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle

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12 December 2020

A genetic study of x-ray sensitive mutants in yeast

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12 December 2020

A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination

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12 December 2020

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

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12 December 2020

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

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12 December 2020

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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12 December 2020

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12 December 2020

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.

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12 December 2020

The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks

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12 December 2020

Involvement of novel autophosphorylation sites in ATM activation

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12 December 2020

Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.

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12 December 2020

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

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12 December 2020

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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12 December 2020

BRCT domains: phosphopeptide binding and signaling modules

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12 December 2020

HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response

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12 December 2020

Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.

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12 December 2020

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

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12 December 2020

The role of DNA damage response proteins at telomeres--an "integrative" model

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12 December 2020

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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12 December 2020

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

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12 December 2020

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

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12 December 2020

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

1 reference

12 December 2020

Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2

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12 December 2020

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

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12 December 2020

Positional cloning of the gene for Nijmegen breakage syndrome

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12 December 2020

The DNA damage response: ten years after

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12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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12 December 2020

Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency

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12 December 2020

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

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12 December 2020

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1 reference

12 December 2020

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

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12 December 2020

A glycine-arginine domain in control of the human MRE11 DNA repair protein

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12 December 2020

Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis.

1 reference

12 December 2020

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

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12 December 2020

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

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12 December 2020

Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

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12 December 2020

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

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12 December 2020

Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions

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12 December 2020

Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

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12 December 2020

The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control

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12 December 2020

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

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12 December 2020

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

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12 December 2020

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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12 December 2020

Mre11: roles in DNA repair beyond homologous recombination.

1 reference

12 December 2020

The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

1 reference

12 December 2020

Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae

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12 December 2020

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.

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12 December 2020

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

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12 December 2020

SOSS complexes participate in the maintenance of genomic stability

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12 December 2020

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

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12 December 2020

A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene

1 reference

12 December 2020

Human CtIP promotes DNA end resection

1 reference

12 December 2020

The FHA domain is a modular phosphopeptide recognition motif.

1 reference

12 December 2020

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

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12 December 2020

DNA damage signalling guards against activated oncogenes and tumour progression

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12 December 2020

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

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12 December 2020

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

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12 December 2020

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

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12 December 2020

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

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12 December 2020

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

1 reference

12 December 2020

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 reference

12 December 2020

The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients

1 reference

12 December 2020

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain

1 reference

12 December 2020

AdnAB: a new DSB-resecting motor-nuclease from mycobacteria

1 reference

12 December 2020

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

1 reference

12 December 2020

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

1 reference

12 December 2020

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

1 reference

12 December 2020

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

1 reference

12 December 2020

The rad50 signature motif: essential to ATP binding and biological function

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12 December 2020

Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae

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12 December 2020

Multiple roles for MRE11 at uncapped telomeres

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12 December 2020

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

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12 December 2020

Requirement of the MRN complex for ATM activation by DNA damage

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12 December 2020

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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12 December 2020

Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage

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12 December 2020

The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle

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12 December 2020

Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination

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12 December 2020

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12 December 2020

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

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12 December 2020

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

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12 December 2020

Evaluation ofRAD50 in familial breast cancer predisposition

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12 December 2020

Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif.

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12 December 2020

Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

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12 December 2020

Regulation of DNA double-strand break repair pathway choice

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12 December 2020

Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination

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12 December 2020

DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

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12 December 2020

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks

1 reference

12 December 2020

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

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12 December 2020

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

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12 December 2020

ATM-dependent phosphorylation of nibrin in response to radiation exposure

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12 December 2020

The Rad50 hook domain is a critical determinant of Mre11 complex functions

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12 December 2020

Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.

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12 December 2020

Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.

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12 December 2020

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

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12 December 2020

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

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12 December 2020

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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12 December 2020

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

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12 December 2020

RAD50 protein of S.cerevisiae exhibits ATP-dependent DNA binding

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12 December 2020

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

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12 December 2020

Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism

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12 December 2020

The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

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12 December 2020

DNA damage-dependent nuclear dynamics of the Mre11 complex

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12 December 2020

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

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12 December 2020

Multiple functions of MRN in end-joining pathways during isotype class switching

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12 December 2020

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins

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12 December 2020

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

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12 December 2020

Quality control of DNA break metabolism: in the 'end', it's a good thing

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12 December 2020

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

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12 December 2020

mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis

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12 December 2020

A DNA damage response pathway controlled by Tel1 and the Mre11 complex

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12 December 2020

Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

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12 December 2020

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer

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12 December 2020

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

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12 December 2020

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

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12 December 2020

Complex formation and functional versatility of Mre11 of budding yeast in recombination

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12 December 2020

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

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12 December 2020

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity

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12 December 2020

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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12 December 2020

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

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12 December 2020

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

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12 December 2020

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

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12 December 2020

Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks

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12 December 2020

Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis

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12 December 2020

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

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12 December 2020

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling

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12 December 2020

Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain

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12 December 2020

The endless tale of non-homologous end-joining

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12 December 2020

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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12 December 2020

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

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12 December 2020

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

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12 December 2020

Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

1 reference

12 December 2020

Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine

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12 December 2020

CDK targets Sae2 to control DNA-end resection and homologous recombination

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12 December 2020

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

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12 December 2020

Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast

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12 December 2020

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

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12 December 2020

Three classes of genes mutated in colorectal cancers with chromosomal instability.

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12 December 2020

Activation of the cellular DNA damage response in the absence of DNA lesions

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12 December 2020

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

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12 December 2020

Nonhomologous end joining in yeast

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12 December 2020

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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12 December 2020

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

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12 December 2020

Dimerization of the Rad50 protein is independent of the conserved hook domain.

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12 December 2020

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

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12 December 2020

Differential regulation of the cellular response to DNA double-strand breaks in G1.

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12 December 2020

Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1

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12 December 2020

The FHA domain mediates phosphoprotein interactions.

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12 December 2020

Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation

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12 December 2020

The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break

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12 December 2020

Tip60 in DNA damage response and growth control: many tricks in one HAT.

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12 December 2020

The BRCT Domain Is a Phospho-Protein Binding Domain

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12 December 2020

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

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12 December 2020

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

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12 December 2020

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation

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12 December 2020

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

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12 December 2020

Double functions for the Mre11 complex during DNA double-strand break repair and replication

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12 December 2020

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

The yeast Xrs2 complex functions in S phase checkpoint regulation

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12 December 2020

SOSS1/2: Sensors of single-stranded DNA at a break

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12 December 2020

NBS1 regulates a novel apoptotic pathway through Bax activation

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12 December 2020

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

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12 December 2020

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

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12 December 2020

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

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12 December 2020

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

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12 December 2020

10.1007/S00412-009-0242-4

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19862546