MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks (Q24299852)

6

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author name string

Manuel Stucki

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Julie A Clapperton

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Duaa Mohammad

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Michael B Yaffe

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

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publication date

29 December 2005

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language of work or name

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123

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issue

7

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page(s)

1213-26

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cites work

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

H2AX: the histone guardian of the genome

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Control of sister chromatid recombination by histone H2AX.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Interactions between BRCT repeats and phosphoproteins: tangled up in two

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Histone H2A variants H2AX and H2AZ

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

MDC1 is required for the intra-S-phase DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

MDC1 regulates DNA-PK autophosphorylation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Megabase chromatin domains involved in DNA double-strand breaks in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Phase combination and cross validation in iterated density-modification calculations

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Automated MAD and MIR structure solution

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Genomic instability in mice lacking histone H2AX

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

The BRCT Domain Is a Phospho-Protein Binding Domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021

Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.09.038

7 January 2021