The ubiquitous role of ubiquitin in the DNA damage response (Q37807639)

23 August 2017

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14 July 2021

The ubiquitous role of ubiquitin in the DNA damage response (English)

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23 August 2017

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14 July 2021

7

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23 August 2017

Abdallah Al-Hakim

1

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23 August 2017

Cristina Escribano-Diaz

2

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23 August 2017

Marie-Claude Landry

3

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23 August 2017

Lara O'Donnell

4

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23 August 2017

Stephanie Panier

5

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23 August 2017

Rachel K Szilard

6

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23 August 2017

4 November 2010

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23 August 2017

10 December 2010

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14 July 2021

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23 August 2017

14 July 2021

9

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23 August 2017

1229-1240

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23 August 2017

12

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Emerging roles of desumoylating enzymes

23 August 2017

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12 December 2020

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

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12 December 2020

Deubiquitination of FANCD2 is required for DNA crosslink repair

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12 December 2020

Defining polyubiquitin chain topology

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12 December 2020

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

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12 December 2020

Ubiquitination of PCNA and the polymerase switch in human cells

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12 December 2020

The fast-growing business of SUMO chains

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12 December 2020

Histone ubiquitination associates with BRCA1-dependent DNA damage response

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12 December 2020

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

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12 December 2020

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

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12 December 2020

RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis

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12 December 2020

Protein regulation by monoubiquitin

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12 December 2020

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

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12 December 2020

Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

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12 December 2020

UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

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12 December 2020

Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors

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12 December 2020

The SUMO-specific protease SENP5 is required for cell division

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12 December 2020

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

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12 December 2020

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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12 December 2020

Polyubiquitin binding and disassembly by deubiquitinating enzymes

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12 December 2020

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

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12 December 2020

Fanconi anemia and DNA replication repair

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12 December 2020

Identification of the Fanconi anemia complementation group I gene, FANCI.

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12 December 2020

Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes

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12 December 2020

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

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12 December 2020

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

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12 December 2020

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

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12 December 2020

The SCF ubiquitin ligase: insights into a molecular machine

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12 December 2020

Human claspin is required for replication checkpoint control

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12 December 2020

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining

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12 December 2020

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

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12 December 2020

The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase.

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12 December 2020

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division

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12 December 2020

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

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12 December 2020

Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.

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12 December 2020

Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

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12 December 2020

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1

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12 December 2020

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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12 December 2020

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown

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12 December 2020

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.

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12 December 2020

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

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12 December 2020

Cell-cycle checkpoints and cancer

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12 December 2020

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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12 December 2020

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

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12 December 2020

Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint

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12 December 2020

The Mre11 complex is required for ATM activation and the G2/M checkpoint

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12 December 2020

Effects of ionizing radiation on cells from Fanconi's anemia patients

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12 December 2020

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

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12 December 2020

"Covalent affinity" purification of ubiquitin-activating enzyme

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12 December 2020

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

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12 December 2020

Mechanisms of polycomb gene silencing: knowns and unknowns

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12 December 2020

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12 December 2020

Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

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12 December 2020

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

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12 December 2020

Defining the human deubiquitinating enzyme interaction landscape

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12 December 2020

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

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12 December 2020

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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12 December 2020

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

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12 December 2020

CCDC98 targets BRCA1 to DNA damage sites

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12 December 2020

53BP1, a mediator of the DNA damage checkpoint

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12 December 2020

Principles of ubiquitin and SUMO modifications in DNA repair.

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12 December 2020

Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly

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12 December 2020

Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

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12 December 2020

53BP1 is required for class switch recombination

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12 December 2020

Common mechanisms of PIKK regulation

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12 December 2020

Getting into position: the catalytic mechanisms of protein ubiquitylation

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12 December 2020

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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12 December 2020

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

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12 December 2020

Breaking the chains: structure and function of the deubiquitinases

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12 December 2020

A proteolytic pathway that recognizes ubiquitin as a degradation signal

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12 December 2020

Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain

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12 December 2020

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

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12 December 2020

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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12 December 2020

Human USP3 is a chromatin modifier required for S phase progression and genome stability

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12 December 2020

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

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12 December 2020

Rapid destruction of human Cdc25A in response to DNA damage

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12 December 2020

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

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12 December 2020

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

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12 December 2020

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

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12 December 2020

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

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12 December 2020

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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12 December 2020

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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12 December 2020

More modifiers move on DNA damage

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12 December 2020

SUMO: a history of modification

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12 December 2020

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

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12 December 2020

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

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12 December 2020

Mechanisms underlying ubiquitination

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12 December 2020

Structural properties of polyubiquitin chains in solution

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12 December 2020

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

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12 December 2020

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

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12 December 2020

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

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12 December 2020

Rapid spontaneous accessibility of nucleosomal DNA.

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12 December 2020

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

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12 December 2020

Regulation of DNA repair by ubiquitylation

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12 December 2020

Stabilizers and Destabilizers Controlling Cell Cycle Oscillators

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12 December 2020

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

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12 December 2020

Chk1 is required to maintain claspin stability

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12 December 2020

Regulation of APC/C activators in mitosis and meiosis

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12 December 2020

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

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12 December 2020

A proteomics approach to understanding protein ubiquitination

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12 December 2020

Regulatory ubiquitylation in response to DNA double-strand breaks

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12 December 2020

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

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12 December 2020

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

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12 December 2020

A genomic and functional inventory of deubiquitinating enzymes

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12 December 2020

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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12 December 2020

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

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12 December 2020

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

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12 December 2020

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

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12 December 2020

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

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12 December 2020

MDC1 is a mediator of the mammalian DNA damage checkpoint

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12 December 2020

Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction

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12 December 2020

Protein partners of deubiquitinating enzymes

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12 December 2020

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair

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12 December 2020

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

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12 December 2020

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

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12 December 2020

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

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12 December 2020

Mechanisms of dealing with DNA damage-induced replication problems

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12 December 2020

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

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12 December 2020

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

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12 December 2020

Requirement of the MRN complex for ATM activation by DNA damage

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12 December 2020

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation

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12 December 2020

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

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12 December 2020

Structural basis and specificity of human otubain 1-mediated deubiquitination

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12 December 2020

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12 December 2020

Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

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12 December 2020

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

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12 December 2020

FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination.

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12 December 2020

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

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12 December 2020

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

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12 December 2020

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

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12 December 2020

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

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12 December 2020

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

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12 December 2020

SUMO in the mammalian response to DNA damage.

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12 December 2020

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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12 December 2020

Regulation of monoubiquitinated PCNA by DUB autocleavage

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12 December 2020

Brca1 controls homology-directed DNA repair

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12 December 2020

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

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12 December 2020

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

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12 December 2020

The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions

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12 December 2020

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

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12 December 2020

FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair

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12 December 2020

A ubiquitin ligase complex assembles linear polyubiquitin chains

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12 December 2020

A major switch for the Fanconi anemia DNA damage-response pathway

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12 December 2020

Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups

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12 December 2020

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

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12 December 2020

Regulation of cell cycle progression and gene expression by H2A deubiquitination

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12 December 2020

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

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12 December 2020

A novel diagnostic screen for defects in the Fanconi anemia pathway

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12 December 2020

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

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12 December 2020

ATM and ATR: components of an integrated circuit

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12 December 2020

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

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12 December 2020

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

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12 December 2020

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

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12 December 2020

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

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12 December 2020

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

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12 December 2020

Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1

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12 December 2020

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

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12 December 2020

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

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12 December 2020

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

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12 December 2020

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

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12 December 2020

Distinct monoubiquitin signals in receptor endocytosis

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12 December 2020

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

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12 December 2020

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

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12 December 2020

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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12 December 2020

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

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12 December 2020

Ubiquitin-dependent DNA damage bypass is separable from genome replication

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12 December 2020

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

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12 December 2020

Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.

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12 December 2020

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

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12 December 2020

The anaphase promoting complex/cyclosome: a machine designed to destroy

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12 December 2020

Surviving the breakup: the DNA damage checkpoint.

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12 December 2020

NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling

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12 December 2020

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

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12 December 2020

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

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12 December 2020

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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12 December 2020

Recognition of the polyubiquitin proteolytic signal

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12 December 2020

Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.

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12 December 2020

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

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12 December 2020

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination

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12 December 2020

Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function

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12 December 2020

The emerging complexity of protein ubiquitination

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12 December 2020

The emerging genetic and molecular basis of Fanconi anaemia

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12 December 2020

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

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12 December 2020

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint

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12 December 2020

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

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12 December 2020

DNA Repair Has a New FAN1 Club

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12 December 2020

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

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12 December 2020

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

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12 December 2020

Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling

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12 December 2020

UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination

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12 December 2020

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

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12 December 2020

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

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12 December 2020

PCNA, the maestro of the replication fork

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12 December 2020

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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12 December 2020

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

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12 December 2020

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

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12 December 2020

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

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12 December 2020

DNA damage signaling in response to double-strand breaks during mitosis

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12 December 2020

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

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12 December 2020

Ubiquitylation and cell signaling

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12 December 2020

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

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12 December 2020

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

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12 December 2020

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

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12 December 2020

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

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12 December 2020

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

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12 December 2020

10.1016/J.DNAREP.2010.09.011

Identifiers

DOI

1 reference

23 August 2017

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