RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins (Q24309287)

histone H2A K63-linked ubiquitination

GOA release 2020-03-11

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GOA release 2020-03-11

author

Daniel Durocher

9

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Stephanie Panier

8

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Jan Ellenberg

7

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Jiří Bártek

10

Jiri Bartek

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Jiří Lukáš

11

Jiri Lukas

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Dorthe H Larsen

Dorthe Helena Larsen

5

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Claudia Lukas

Claudia Lukas

12

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Simon Bekker-Jensen

Simon Bekker-Jensen

3

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Rainer Pepperkok

Rainer Pepperkok

6

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author name string

Carsten Doil

1

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Niels Mailand

2

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Patrice Menard

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

4

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publication date

6 February 2009

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language of work or name

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136

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issue

3

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page(s)

435-46

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Human USP3 is a chromatin modifier required for S phase progression and genome stability

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

H2AX: the histone guardian of the genome

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Clonogenic assay of cells in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Reverse transfection on cell arrays for high content screening microscopy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Cellular functions of the BRCA tumour-suppressor proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Activation of the cellular DNA damage response in the absence of DNA lesions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021

Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.12.041

7 January 2021