The anaphase promoting complex/cyclosome: a machine designed to destroy (Q29618398)

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title

The anaphase promoting complex/cyclosome: a machine designed to destroy (English)

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30 April 2017

author name string

Peters JM

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30 April 2017

language of work or name

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30 April 2017

publication date

September 2006

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

volume

7

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30 April 2017

page(s)

644-56

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issue

9

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Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

30 April 2017

cites work

1 reference

Functional analysis of the Saccharomyces cerevisiae UBC11 gene

1 May 2017

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The Doc1 subunit is a processivity factor for the anaphase-promoting complex.

1 May 2017

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Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC.

1 May 2017

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Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.

1 May 2017

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TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1

1 May 2017

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The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

1 May 2017

1 reference

Cyclin is degraded by the ubiquitin pathway

1 May 2017

1 reference

Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit

1 May 2017

1 reference

Identification of a cullin homology region in a subunit of the anaphase-promoting complex

1 May 2017

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Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

1 May 2017

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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

1 May 2017

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Function and regulation of cullin-RING ubiquitin ligases

1 May 2017

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Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C

1 May 2017

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An architectural map of the anaphase-promoting complex

1 May 2017

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CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

1 May 2017

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The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner

1 May 2017

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Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

1 May 2017

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Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex

1 May 2017

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Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit

1 May 2017

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Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex

1 May 2017

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The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll

1 May 2017

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Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast

1 May 2017

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Temporal and spatial control of cyclin B1 destruction in metaphase

1 May 2017

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 May 2017

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

1 May 2017

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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

1 May 2017

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The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis

1 May 2017

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Securin is required for chromosomal stability in human cells

1 May 2017

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APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.

1 May 2017

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Mitotic regulation of the human anaphase-promoting complex by phosphorylation

1 May 2017

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Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

1 May 2017

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

1 May 2017

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The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1 May 2017

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Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

1 May 2017

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E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

1 May 2017

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Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

1 May 2017

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Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

1 May 2017

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APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box

1 May 2017

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The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

1 May 2017

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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

1 May 2017

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Budding yeast Cdc20: a target of the spindle checkpoint.

1 May 2017

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

1 May 2017

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

1 May 2017

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Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

1 May 2017

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The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

1 May 2017

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Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

1 May 2017

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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

1 May 2017

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Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

1 May 2017

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Mad2 transiently associates with an APC/p55Cdc complex during mitosis

1 May 2017

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Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

1 May 2017

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Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

1 May 2017

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Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

1 May 2017

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Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

1 May 2017

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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

1 May 2017

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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

1 May 2017

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Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast

1 May 2017

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The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.

1 May 2017

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Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.

1 May 2017

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Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes

1 May 2017

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Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex.

1 May 2017

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Emi1 is required for cytostatic factor arrest in vertebrate eggs

1 May 2017

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Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20.

1 May 2017

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How proteolysis drives the cell cycle

1 May 2017

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CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1 May 2017

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Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1)

1 May 2017

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The spindle checkpoint requires cyclin-dependent kinase activity

1 May 2017

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Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1

1 May 2017

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MAD2B is an inhibitor of the anaphase-promoting complex

1 May 2017

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Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

1 May 2017

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The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

1 May 2017

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Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae

1 May 2017

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The anaphase-promoting complex: proteolysis in mitosis and beyond

1 May 2017

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The anaphase-promoting complex: it's not just for mitosis any more.

31 March 2020

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E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins

31 March 2020

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Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation

31 March 2020

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Two Ubiquitin-Conjugating Enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, Have Distinct Functions for Ubiquitination of Mitotic Cyclin

31 March 2020

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The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

31 March 2020

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Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

31 March 2020

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APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex

31 March 2020

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The APC11 RING-H2 finger mediates E2-dependent ubiquitination

31 March 2020

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Getting into position: the catalytic mechanisms of protein ubiquitylation

31 March 2020

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The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

31 March 2020

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Three-dimensional structure of the anaphase-promoting complex

31 March 2020

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Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation

31 March 2020

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Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

31 March 2020

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Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

31 March 2020

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Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities

31 March 2020

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Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex

31 March 2020

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D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p

31 March 2020

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Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

31 March 2020

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A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

31 March 2020

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Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts

31 March 2020

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Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition

31 March 2020

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Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.

31 March 2020

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The APC subunit Doc1 promotes recognition of the substrate destruction box.

31 March 2020

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Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

31 March 2020

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Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast

31 March 2020

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A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

31 March 2020

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The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

31 March 2020

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Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

31 March 2020

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Regulation of early events in chromosome replication

31 March 2020

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

31 March 2020

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Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis

31 March 2020

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Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae

31 March 2020

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Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts

31 March 2020

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Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division

31 March 2020

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Dual inhibition of sister chromatid separation at metaphase.

31 March 2020

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Mutual inhibition of separase and Cdk1 by two-step complex formation

31 March 2020

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Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation

31 March 2020

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Securin and B-cyclin/CDK are the only essential targets of the APC.

31 March 2020

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Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.

31 March 2020

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Mitotic regulation of the APC activator proteins CDC20 and CDH1

31 March 2020

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Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

31 March 2020

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The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

31 March 2020

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APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.

31 March 2020

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Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation

31 March 2020

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The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

31 March 2020

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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

31 March 2020

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The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis.

31 March 2020

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Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

31 March 2020

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Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.

31 March 2020

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Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A.

31 March 2020

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Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2.

31 March 2020

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Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

31 March 2020

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Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

31 March 2020

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Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome

31 March 2020

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Involvement of the SCF complex in the control of Cdh1 degradation in S-phase

31 March 2020

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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

31 March 2020

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Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

31 March 2020

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The spindle checkpoint: structural insights into dynamic signalling

31 March 2020

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

31 March 2020

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Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

31 March 2020

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Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

31 March 2020

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The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

31 March 2020

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Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

31 March 2020

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Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

31 March 2020

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Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

31 March 2020

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Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.

31 March 2020

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Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

31 March 2020

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Regulation of the cyclin B degradation system by an inhibitor of mitotic proteolysis

31 March 2020

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Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs

31 March 2020

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Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation

31 March 2020

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Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest

31 March 2020

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Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest

31 March 2020

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Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

31 March 2020

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Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity

31 March 2020

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A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs

31 March 2020

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CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit

31 March 2020

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The anaphase promoting complex/cyclosome is required during development for modified cell cycles

31 March 2020

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CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

31 March 2020

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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

31 March 2020

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Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

31 March 2020

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The processivity of multiubiquitination by the APC determines the order of substrate degradation.

31 March 2020

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The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

31 March 2020

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The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells

31 March 2020

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The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time

31 March 2020

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Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos.

31 March 2020

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Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint

31 March 2020

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Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint.

31 March 2020

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Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase

31 March 2020

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The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

31 March 2020

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The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.

31 March 2020

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Human cytomegalovirus inactivates the G0/G1-APC/C ubiquitin ligase by Cdh1 dissociation.

31 March 2020

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Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome

31 March 2020

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31 March 2020

Identifiers

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

100746

1053705055

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Consolidated OpenCitations Corpus – April 2017