Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 (Q33839896)

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30 January 2020

title

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 (English)

1 reference

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30 January 2020

author

Andrés J López-Contreras

5

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Óscar Fernández-Capetillo

30 January 2020

9

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30 January 2020

7

Nancy Wong

1 reference

30 January 2020

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author name string

Margarida Almeida Santos

1

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30 January 2020

Michael S Y Huen

2

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30 January 2020

Mila Jankovic

3

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30 January 2020

Hua-Tang Chen

4

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30 January 2020

Isaac A Klein

6

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30 January 2020

Juan L R Barbancho

8

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30 January 2020

Junjie Chen

11

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30 January 2020

André Nussenzweig

12

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30 January 2020

Michel C Nussenzweig

10

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30 January 2020

language of work or name

English

0 references

publication date

12 April 2010

1 reference

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Journal of Experimental Medicine

30 January 2020

published in

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30 January 2020

volume

207

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30 January 2020

issue

5

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30 January 2020

page(s)

973-981

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The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

30 January 2020

cites work

1 reference

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Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

5 July 2018

1 reference

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RAD18 transmits DNA damage signalling to elicit homologous recombination repair

5 July 2018

1 reference

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Monoubiquitylation in the Fanconi anemia DNA damage response pathway

5 July 2018

1 reference

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Regulatory ubiquitylation in response to DNA double-strand breaks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

5 July 2018

1 reference

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

5 July 2018

1 reference

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53BP1 facilitates long-range DNA end-joining during V(D)J recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

5 July 2018

1 reference

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ATM prevents the persistence and propagation of chromosome breaks in lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

5 July 2018

1 reference

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

ATM is required for efficient recombination between immunoglobulin switch regions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

53BP1 is required for class switch recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

H2AX regulates meiotic telomere clustering

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Genomic instability in mice lacking histone H2AX

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867275

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20092308

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20385748

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20092308

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385748%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385748%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference