Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation (Q24670580)

6

object named as

Jiri Lukas

0 references

Claudia Lukas

object named as

Claudia Lukas

4

0 references

Simon Bekker-Jensen

object named as

Simon Bekker-Jensen

2

0 references

author name string

Shizhou Liu

1

0 references

Niels Mailand

Molecular and Cellular Biology

3

0 references

language of work or name

English

0 references

publication date

August 2006

0 references

published in

0 references

volume

26

0 references

page(s)

6056-64

0 references

issue

16

0 references

cites work

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

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DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

7 April 2017

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TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival

7 April 2017

1 reference

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Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1

7 April 2017

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MDC1 is a mediator of the mammalian DNA damage checkpoint

7 April 2017

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A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

7 April 2017

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

7 April 2017

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A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator

7 April 2017

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

7 April 2017

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

7 April 2017

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Mrc1 transduces signals of DNA replication stress to activate Rad53.

7 April 2017

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The DNA damage response: putting checkpoints in perspective

7 April 2017

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

7 April 2017

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Claspin, a regulator of Chk1 in DNA replication stress pathway

7 April 2017

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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes

7 April 2017

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

7 April 2017

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

7 April 2017

1 reference

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Human claspin is required for replication checkpoint control

7 April 2017

1 reference

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Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

7 April 2017

1 reference

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

7 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Rapid destruction of human Cdc25A in response to DNA damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

TopBP1 activates the ATR-ATRIP complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Chk1 and Chk2 kinases in checkpoint control and cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Cell cycle checkpoint signaling through the ATM and ATR kinases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Human TopBP1 ensures genome integrity during normal S phase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Identification and functional analysis of TopBP1 and its homologs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

ATRIP oligomerization is required for ATR-dependent checkpoint signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592810