Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair (Q22009084)

Ubiquitin conjugating enzyme E2 V1

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Ubiquitin conjugating enzyme E2 N

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regulation of DNA repair

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E2 ubiquitin-conjugating protein UBC13 YDR092W

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E2 ubiquitin-conjugating protein MMS2 YGL087C

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A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains

R M Hofmann

1

R M

Hofmann

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7 February 2023

C M Pickart

series ordinal

2

author given names

C M

author last names

Pickart

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7 February 2023

language of work or name

English

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publication date

5 March 1999

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published in

Cell

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volume

96

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page(s)

645-53

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issue

5

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cites work

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7 January 2021

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites

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7 January 2021

Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities

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7 January 2021

Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting

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7 January 2021

The hydrophobic effect contributes to polyubiquitin chain recognition

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MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway

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7 January 2021

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

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Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor

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7 January 2021

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

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Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: crystal structure of yeast Ubc4

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7 January 2021

Structure of tetraubiquitin shows how multiubiquitin chains can be formed

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7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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7 January 2021

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

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7 January 2021

Pathways of ubiquitin conjugation.

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Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element.

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7 January 2021

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

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7 January 2021

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

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7 January 2021

Ubiquitin-dependent protein degradation

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7 January 2021

The tail of a ubiquitin-conjugating enzyme redirects multi-ubiquitin chain synthesis from the lysine 48-linked configuration to a novel nonlysine-linked form

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7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

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7 January 2021

TSG101 may be the prototype of a class of dominant negative ubiquitin regulators

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7 January 2021

Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity

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Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

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Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines

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7 January 2021

The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes

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7 January 2021

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5

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7 January 2021

bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog

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7 January 2021

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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7 January 2021

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths

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7 January 2021

DNA repair genes and proteins of Saccharomyces cerevisiae

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RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates

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7 January 2021

Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

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7 January 2021

Expression of argU, the Escherichia coli gene coding for a rare arginine tRNA

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7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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7 January 2021

A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

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7 January 2021

Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage.

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7 January 2021

Requirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair

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The N-end rule: functions, mysteries, uses

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The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family

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7 January 2021

Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency

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7 January 2021

Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product

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7 January 2021