Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue (Q28066868)

Motonari Nomura

series ordinal

2

1 reference

Ryan Shuck

series ordinal

3

1 reference

Jason Yustein

series ordinal

4

1 reference

International Journal of Molecular Sciences

language of work or name

1 reference

23 December 2016

5 references

3 April 2019

20 December 2020

8 February 2021

3 October 2022

4 references

3 April 2019

20 December 2020

8 February 2021

3 October 2022

18

1 reference

page(s)

23

0 references

issue

1

1 reference

Creative Commons Attribution

copyright license

4 references

3 April 2019

20 December 2020

8 February 2021

3 October 2022

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models

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The concept of synthetic lethality in the context of anticancer therapy

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The Hallmarks of Cancer

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Caspases: enemies within

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7 April 2017

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Identification of RIP1 kinase as a specific cellular target of necrostatins

7 April 2017

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 April 2017

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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Improved survival with MEK inhibition in BRAF-mutated melanoma

7 April 2017

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

7 April 2017

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Restoration of p53 function leads to tumour regression in vivo

7 April 2017

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Chk1 and Chk2 kinases in checkpoint control and cancer

7 April 2017

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Two CD95 (APO-1/Fas) signaling pathways

7 April 2017

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A fate worse than death: apoptosis as an oncogenic process

7 April 2017

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The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors

29 September 2017

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29 September 2017

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29 September 2017

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Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy

29 September 2017

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Drugging the undruggable RAS: Mission possible?

29 September 2017

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29 September 2017

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29 September 2017

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Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

29 September 2017

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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

29 September 2017

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Caspase functions in cell death and disease

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

29 September 2017

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29 September 2017

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29 September 2017

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Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

29 September 2017

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The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells

29 September 2017

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AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics.

29 September 2017

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Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

29 September 2017

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

29 September 2017

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29 September 2017

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BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

29 September 2017

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The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

29 September 2017

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Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

29 September 2017

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RIP kinases at the crossroads of cell death and survival

29 September 2017

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XIAP discriminates between type I and type II FAS-induced apoptosis

29 September 2017

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Human caspases: activation, specificity, and regulation

29 September 2017

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

29 September 2017

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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

29 September 2017

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Bcl-2 family proteins and cancer

29 September 2017

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A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

29 September 2017

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

29 September 2017

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Small-molecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer.

29 September 2017

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

29 September 2017

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X-linked inhibitor of apoptosis protein as a therapeutic target

29 September 2017

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Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

29 September 2017

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Synthetic lethal screen identification of chemosensitizer loci in cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Note on the origin and history of the term "apoptosis".

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Control of apoptosis by p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Breast and ovarian cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

The Apaf-1 apoptosome: a large caspase-activating complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Apoptosis in neurodegenerative disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Corpse clearance defines the meaning of cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

The morphology of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

PARP inhibitors: the race is on.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Apoptosis: Stabbed in the BAX.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5297658

Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.

2 June 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Cell survival in tough times: The mitochondrial recovery plan.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Lung-cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells--response.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Programmed cell death: Apoptosis meets necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18010023

Necroptosis: a specialized pathway of programmed necrosis

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/28025559

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Involvement of the bcl-2 gene in human follicular lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28025559