Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia (Q35524250)

8 August 2017

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia (English)

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8 August 2017

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Steven M Chan

1

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8 August 2017

Daniel Thomas

2

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8 August 2017

M Ryan Corces-Zimmerman

3

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8 August 2017

Seethu Xavy

4

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8 August 2017

Suchita Rastogi

5

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8 August 2017

Wan-Jen Hong

6

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8 August 2017

Feifei Zhao

7

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8 August 2017

Bruno C Medeiros

8

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8 August 2017

David A Tyvoll

9

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8 August 2017

Ravindra Majeti

10

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8 August 2017

language of work or name

English

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publication date

19 January 2015

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8 August 2017

7

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inferred from page(s)

published in

Nature Medicine

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8 August 2017

21

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8 August 2017

2

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8 August 2017

178-184

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https://scigraph.springernature.com/pub.10.1038/nm.3788

8 August 2017

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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

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An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation

12 July 2018

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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

12 July 2018

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Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia

12 July 2018

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Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death

12 July 2018

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BH3 profiling in whole cells by fluorimeter or FACS

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In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice

12 July 2018

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

12 July 2018

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

12 July 2018

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BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

12 July 2018

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

12 July 2018

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

12 July 2018

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

12 July 2018

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Spectrum of somatic mitochondrial mutations in five cancers

12 July 2018

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

12 July 2018

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

12 July 2018

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

12 July 2018

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2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

12 July 2018

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Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

12 July 2018

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Targeting the mitochondrial electron transport chain complexes for the induction of apoptosis and cancer treatment

12 July 2018

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Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

12 July 2018

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Anticancer drugs targeting the mitochondrial electron transport chain

12 July 2018

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Revisiting the TCA cycle: signaling to tumor formation

12 July 2018

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

12 July 2018

1 reference

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

12 July 2018

1 reference

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

12 July 2018

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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.

12 July 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

12 July 2018

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Recurring mutations found by sequencing an acute myeloid leukemia genome

12 July 2018

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Noxa: at the tip of the balance between life and death.

12 July 2018

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BAD: undertaker by night, candyman by day.

12 July 2018

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Mimicking the BH3 domain to kill cancer cells

12 July 2018

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Principles of cancer therapy: oncogene and non-oncogene addiction

12 July 2018

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IDH1 and IDH2 mutations in gliomas

12 July 2018

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Stem cell concepts renew cancer research

12 July 2018

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An integrated genomic analysis of human glioblastoma multiforme

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Role of Bcl-2 family members in anoxia induced cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

mTOR regulates cell survival after etoposide treatment in primary AML cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Cyanide intoxication and its mechanism of antagonism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Structure and function of cytochrome c oxidase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Resolution of the electronic transitions of cytochrome c oxidase: evidence for two conformational states of ferrous cytochrome alpha

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Binding of ligands and spectral shifts in cytochrome c oxidase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

D-2-Hydroxyglutaric aciduria in a patient with a severe clinical phenotype and unusual MRI findings

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406275

Characterization and prognostic significance of mitochondrial DNA variations in acute myeloid leukemia

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3788

BCL-2 inhibitor yields high response in CLL and SLL

21 January 2018

1 reference

12 December 2020

Effects of overall oxidation state on infrared spectra of heme a3 cyanide in bovine heart cytochrome c oxidase. Evidence of novel mechanistic roles for CuB

1 reference

12 December 2020

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

1 reference

12 December 2020

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3788

1 reference

8 August 2017

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8 August 2017

1 reference