Molecular Cell Biology of Apoptosis and Necroptosis in Cancer. (Q50221065)

27 February 2018

review article

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title

Molecular Cell Biology of Apoptosis and Necroptosis in Cancer. (English)

1 reference

27 February 2018

1 reference

1 reference

Douglas R Green

2

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author name string

Christopher P Dillon

series ordinal

1

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27 February 2018

language of work or name

English

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publication date

1 January 2016

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27 February 2018

Advances in Experimental Medicine and Biology

published in

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27 February 2018

volume

930

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27 February 2018

page(s)

1-23

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27 February 2018

The age distribution of cancer and a multi-stage theory of carcinogenesis

cites work

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Apoptosis: controlled demolition at the cellular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Regulated cell death: signaling and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Death by caspase dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Molecular cell death platforms and assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Mitochondrial regulation of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

21 January 2018

The BCL-2 family reunion

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Adult Apaf-1-deficient mice exhibit male infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Differential requirement for caspase 9 in apoptotic pathways in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Integral role of Noxa in p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Delving deeper: MCL-1's contributions to normal and cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Apoptosis and the homeostatic control of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A role for proapoptotic Bax and Bak in T-cell differentiation and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The role of Bcl-2 family members in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Small molecule Mcl-1 inhibitors for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The BCL-2 protein family, BH3-mimetics and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Evaluation and critical assessment of putative MCL-1 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Seeking a MCL-1 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Hydrocarbon-stapled peptides: principles, practice, and progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A stapled BID BH3 helix directly binds and activates BAX

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

BH3 mimetics to improve cancer therapy; mechanisms and examples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

New dimension in therapeutic targeting of BCL-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Activation of caspase-2 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2: the orphan caspase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The PIDDosome, DNA-damage-induced apoptosis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Characterization of cytoplasmic caspase-2 activation by induced proximity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2: the reinvented enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

An Inhibitor of PIDDosome Formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2 activation in the absence of PIDDosome formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Defects in regulation of apoptosis in caspase-2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2 deficiency enhances aging-related traits in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2 protects against oxidative stress in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase function in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

PIDDosome-independent tumor suppression by Caspase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A tumor suppressor function for caspase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

An unexpected role for caspase-2 in neuroblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

ATM and ATR as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Signalling pathways of the TNF superfamily: a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase 8 is absent or low in many ex vivo gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Differential inactivation of caspase-8 in lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

CD95 promotes tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Identification of RIP1 kinase as a specific cellular target of necrostatins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

MLKL regulates necrotic plasma membrane permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Switch for the necroptotic permeation pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A plug release mechanism for membrane permeation by MLKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIP3 induces apoptosis independent of pronecrotic kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Dietary modulation of the microbiome affects autoinflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Dynamic expression of epidermal caspase 8 simulates a wound healing response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Therapeutic exploitation of necroptosis for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Broad targeting of resistance to apoptosis in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Death by a thousand cuts: an ever increasing list of caspase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Bcl-2 family proteins are essential for platelet survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase-2/NEDD-2 protease mediates execution of apoptosis in AK-5 tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Biochemistry and function of the DISC

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-39406-0_1

10.1007/978-3-319-39406-0_1

31 March 2020

Identifiers

DOI

1 reference

27 February 2018

PubMed ID

27558815

1 reference

27 February 2018