Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study (Q27851971)

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English	Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study	scientific article

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scholarly article

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13 November 2016

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study (English)

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13 November 2016

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multicenter clinical trial

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based on heuristic

inferred from title

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based on heuristic

inferred from title

1

object named as

Pasi A Jänne

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author name string

Alice T Shaw

2

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José Rodrigues Pereira

3

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Gaëlle Jeannin

4

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Johan Vansteenkiste

5

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Carlos Barrios

6

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Fabio Andre Franke

7

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Lynda Grinsted

8

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Victoria Zazulina

9

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Paul Smith

10

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Ian Smith

11

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Lucio Crinò

12

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publication date

January 2013

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Lancet Oncology Commission

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14

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38-47

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1

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Global cancer statistics

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Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

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Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

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Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer

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The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

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Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

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The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

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Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)

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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

1 reference

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Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy.

1 reference

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Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial

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A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens

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A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy.

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Identifiers

10.1016/S1470-2045(12)70489-8

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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