Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation (Q36691082)

15 August 2017

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title

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation (English)

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15 August 2017

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Sanjeev Mariathasan

1

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PubMed ID

17186029

15 August 2017

Denise M Monack

series ordinal

2

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15 August 2017

1 January 2007

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Nature Reviews Immunology

15 August 2017

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15 August 2017

7

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15 August 2017

31-40

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15 August 2017

1

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Bacterial genomics and pathogen evolution

15 August 2017

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Bacterial adhesion and entry into host cells

31 March 2020

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Toll-like receptor signalling

31 March 2020

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Signalling pathways and molecular interactions of NOD1 and NOD2

31 March 2020

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CATERPILLERs, pyrin and hereditary immunological disorders

31 March 2020

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NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

31 March 2020

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NACHT-LRR proteins (NLRs) in bacterial infection and immunity

31 March 2020

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Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

31 March 2020

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Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

31 March 2020

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

31 March 2020

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

31 March 2020

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The role of Toll-like receptors and Nod proteins in bacterial infection

31 March 2020

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Intracellular pattern recognition receptors in the host response

31 March 2020

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

31 March 2020

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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

31 March 2020

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Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

31 March 2020

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Inhibition of fas death signals by FLIPs

31 March 2020

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A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis

31 March 2020

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Inflammatory caspases and inflammasomes: master switches of inflammation

31 March 2020

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The inflammasome: first line of the immune response to cell stress

31 March 2020

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The inflammasome--a linebacker of innate defense.

31 March 2020

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Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense

31 March 2020

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ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

31 March 2020

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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

31 March 2020

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

31 March 2020

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Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC

31 March 2020

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Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

31 March 2020

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

31 March 2020

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The autoinflammatory syndromes

31 March 2020

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Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

31 March 2020

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Cryopyrin activates the inflammasome in response to toxins and ATP

31 March 2020

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

31 March 2020

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Gout-associated uric acid crystals activate the NALP3 inflammasome

31 March 2020

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

31 March 2020

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Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

31 March 2020

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Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

31 March 2020

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A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection.

31 March 2020

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

31 March 2020

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Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death

31 March 2020

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New insights into the mechanism of IL-1beta maturation

31 March 2020

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Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

31 March 2020

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Interleukin 1 is processed and released during apoptosis

31 March 2020

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Altered cytokine production in mice lacking P2X(7) receptors

31 March 2020

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Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy

31 March 2020

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Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2

31 March 2020

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Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes

31 March 2020

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ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules

31 March 2020

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

31 March 2020

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

31 March 2020

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Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes

31 March 2020

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The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

31 March 2020

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Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB

31 March 2020

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Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation

31 March 2020

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Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

31 March 2020

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Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection

31 March 2020

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Salmonella interactions with host cells: type III secretion at work

31 March 2020

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Enteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitation

31 March 2020

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Bacterial invasion: the paradigms of enteroinvasive pathogens

31 March 2020

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Salmonella type III secretion-associated chaperones confer secretion-pathway specificity

31 March 2020

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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

31 March 2020

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Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila.

31 March 2020

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Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.

31 March 2020

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An exegesis of IAPs: salvation and surprises from BIR motifs

31 March 2020

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Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses

31 March 2020

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Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

31 March 2020

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A process for controlling intracellular bacterial infections induced by membrane injury

31 March 2020

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Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis

31 March 2020

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Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release

31 March 2020

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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

31 March 2020

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PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

31 March 2020

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

31 March 2020

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Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9

31 March 2020

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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

31 March 2020

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ICEBERG: a novel inhibitor of interleukin-1beta generation

31 March 2020

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Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

31 March 2020

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Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing

31 March 2020

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CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

31 March 2020

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INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation

31 March 2020

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Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population.

31 March 2020

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Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis

31 March 2020

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The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production

31 March 2020

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Caspase activation: the induced-proximity model

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1997

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release_l4gspio57rej7po675j5y36jbu

15 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/l4gspio57rej7po675j5y36jbu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

17186029

1 reference

PubMed ID

17186029