Regulated necrosis: the expanding network of non-apoptotic cell death pathways. (Q34039639)

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6 March 2020

title

Regulated necrosis: the expanding network of non-apoptotic cell death pathways (English)

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6 March 2020

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6 March 2020

Andreas Linkermann

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2

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6 March 2020

Sandrine Jouan-Lanhouet

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3

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6 March 2020

Peter Vandenabeele

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6 March 2020

author name string

Henning Walczak

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4

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6 March 2020

publication date

1 February 2014

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Nature Reviews Molecular Cell Biology

6 March 2020

published in

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volume

15

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6 March 2020

page(s)

135-147

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issue

2

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https://scigraph.springernature.com/pub.10.1038/nrm3737

6 March 2020

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Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

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Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

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Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease

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TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

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The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

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Pro-inflammatory programmed cell death

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Recognition of bacteria by inflammasomes

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Salmonella induces macrophage death by caspase-1-dependent necrosis.

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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

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Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

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Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila

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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila

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Non-canonical inflammasome activation targets caspase-11

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Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

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Caspase-11 protects against bacteria that escape the vacuole

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria

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Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome

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Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death

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Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent

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Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome

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Regulation of cell survival and death by pyridine nucleotides

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Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection

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NAD+ metabolism in health and disease

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Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

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Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

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Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice

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Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice.

31 March 2020

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Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

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Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans

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Lysosomal cell death at a glance.

31 March 2020

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Cancer cell injury by cytotoxins from cobra venom is mediated through lysosomal damage

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Stat3 controls lysosomal-mediated cell death in vivo.

31 March 2020

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TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

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Virus inhibition of RIP3-dependent necrosis

31 March 2020

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Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

31 March 2020

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Autoschizis: a novel cell death

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Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione

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Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis

31 March 2020

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

31 March 2020

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

31 March 2020

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Antigen-mediated T cell expansion regulated by parallel pathways of death

31 March 2020

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Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.

31 March 2020

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Shikonin circumvents cancer drug resistance by induction of a necroptotic death

31 March 2020

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Shikonin kills glioma cells through necroptosis mediated by RIP-1

31 March 2020

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Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

31 March 2020

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Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

31 March 2020

1 reference

PKR; a sentinel kinase for cellular stress

31 March 2020

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Necrotic death pathway in Fas receptor signaling

31 March 2020

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

31 March 2020

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

31 March 2020

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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

31 March 2020

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Functional complementation between FADD and RIP1 in embryos and lymphocytes

31 March 2020

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Survival function of the FADD-CASPASE-8-cFLIP(L) complex

31 March 2020

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Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice

31 March 2020

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The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore

31 March 2020

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Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

31 March 2020

1 reference

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

31 March 2020

1 reference

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

31 March 2020

1 reference

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

31 March 2020

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Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

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RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

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A role of RIP3-mediated macrophage necrosis in atherosclerosis development.

31 March 2020

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Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma.

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

31 March 2020

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Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

31 March 2020

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Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

31 March 2020

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12 December 2020

Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition

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12 December 2020

Cell death: multitasking p53 promotes necrosis

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12 December 2020

Sphingosine-induced apoptosis is dependent on lysosomal proteases

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12 December 2020

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

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12 December 2020

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

1 reference

12 December 2020

Mitochondrial permeability transition and cell death: the role of cyclophilin d

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12 December 2020

Quinolinic Acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms

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12 December 2020

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6 March 2020

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