Chk1 and Chk2 kinases in checkpoint control and cancer (Q29617706)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359

30 April 2017

author name string

Bartek J

series ordinal

1

1 reference

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30 April 2017

Lukas J

series ordinal

2

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30 April 2017

publication date

May 2003

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359

30 April 2017

language of work or name

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30 April 2017

1 reference

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30 April 2017

volume

3

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30 April 2017

issue

5

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30 April 2017

page(s)

421-9

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publication type of scholarly work

30 April 2017

review article

1 reference

Cell cycle checkpoint signaling through the ATM and ATR kinases

Europe PubMed Central

cites work

1 reference

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7 January 2021

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

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7 January 2021

Mutation analysis of the CHK2 gene in families with hereditary breast cancer

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7 January 2021

Mammalian G1- and S-phase checkpoints in response to DNA damage

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7 January 2021

CHK2 kinase--a busy messenger.

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7 January 2021

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

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7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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7 January 2021

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

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7 January 2021

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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7 January 2021

ATR and ATRIP: Partners in Checkpoint Signaling

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7 January 2021

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

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7 January 2021

Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function

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7 January 2021

DNA-dependent acetylation of p53 by the transcription coactivator p300.

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7 January 2021

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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7 January 2021

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

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7 January 2021

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

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7 January 2021

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

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7 January 2021

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

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7 January 2021

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

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7 January 2021

MDC1 is required for the intra-S-phase DNA damage checkpoint

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7 January 2021

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

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7 January 2021

Mutations of Chk2 in primary hematopoietic neoplasms

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7 January 2021

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

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7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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7 January 2021

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

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7 January 2021

Genome maintenance mechanisms for preventing cancer

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7 January 2021

Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias

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7 January 2021

Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

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7 January 2021

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

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7 January 2021

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

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7 January 2021

The many substrates and functions of ATM

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7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

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7 January 2021

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

1 reference

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7 January 2021

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

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7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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7 January 2021

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

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7 January 2021

Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer

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7 January 2021

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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7 January 2021

Rapid destruction of human Cdc25A in response to DNA damage

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7 January 2021

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

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7 January 2021

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

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7 January 2021

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

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7 January 2021

Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

1 reference

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7 January 2021

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

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7 January 2021

Analysis of CHK2 in vulval neoplasia

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7 January 2021

Molecular mechanism of the interaction between MDM2 and p53.

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7 January 2021

In search of the tumour-suppressor functions of BRCA1 and BRCA2

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7 January 2021

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility

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7 January 2021

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7 January 2021

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours

1 reference

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7 January 2021

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

1 reference

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7 January 2021

Chk2 activates E2F-1 in response to DNA damage

1 reference

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7 January 2021

MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

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7 January 2021

Concomitant inactivation of p53 and Chk2 in breast cancer

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7 January 2021

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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7 January 2021

Analysis of the CHK2 Gene in Lymphoid Malignancies

1 reference

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7 January 2021

CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7

7 January 2021

A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

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7 January 2021

53BP1, a mediator of the DNA damage checkpoint

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7 January 2021

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

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7 January 2021

Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway

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7 January 2021

Characterization of tumor-associated Chk2 mutations

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7 January 2021

Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2

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7 January 2021

Chk2 activation and phosphorylation-dependent oligomerization

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7 January 2021

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

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7 January 2021

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

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7 January 2021

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

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7 January 2021

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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7 January 2021

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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7 January 2021

The DNA damage response: putting checkpoints in perspective

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7 January 2021

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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7 January 2021

10.1016/S1535-6108(03)00110-7

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359

PubMed publication ID

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017