Checkpoint control and cancer. (Q37941374)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Checkpoint control and cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Libor Macůrek

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

L Macůrek

series ordinal

2

1 reference

25 August 2017

publication date

3 October 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

language of work or name

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

issue

21

1 reference

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13 February 2020

page(s)

2601-2613

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

publication type of scholarly work

13 February 2020

review article

1 reference

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The ups and downs of p53: understanding protein dynamics in single cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Stimulus-dependent dynamics of p53 in single cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Assembly and function of DNA double-strand break repair foci in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Human claspin is required for replication checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

ATR: an essential regulator of genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p53 post-translational modification: deregulated in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Cdc25B activity is regulated by 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Phosphatases in the cellular response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wip1-deficient mice are resistant to common cancer genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Dynamics of the p53-Mdm2 feedback loop in individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

WIP1 phosphatase at the crossroads of cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

53BP1 promotes ATM activity through direct interactions with the MRN complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The roles of p27(Kip1) and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk1 regulates the density of active replication origins during the vertebrate S phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p53-dependent repression of polo-like kinase-1 (PLK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Repo-Man Controls a Protein Phosphatase 1-Dependent Threshold for DNA Damage Checkpoint Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

TAO kinases mediate activation of p38 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Human CtIP promotes DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Recent Advances in the Therapeutic Perspectives of Nutlin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk2 activates E2F-1 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

OsHAL3 mediates a new pathway in the light-regulated growth of rice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Plk1 promotes nuclear translocation of human Cdc25C during prophase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

PPM1D silencing by lentiviral-mediated RNA interference inhibits proliferation and invasion of human glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Chk1 is required for spindle checkpoint function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

The polo-like kinase 1 regulates CDC25B-dependent mitosis entry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas

31 March 2020

1 reference

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CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.451

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.451

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21963855%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference