A decade of caspases (Q35591686)

9 August 2017

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title

A decade of caspases (English)

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9 August 2017

1

Alexei Degterev

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9 August 2017

Michael Boyce

2

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PubMed ID

14634618

9 August 2017

Junying Yuan

series ordinal

3

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PubMed ID

14634618

9 August 2017

language of work or name

English

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publication date

1 November 2003

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9 August 2017

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9 August 2017

22

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9 August 2017

8543-8567

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9 August 2017

53

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207107

9 August 2017

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cites work

Human ICE/CED-3 protease nomenclature

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

RGD peptides induce apoptosis by direct caspase-3 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Molecular cloning of the interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

c-Jun NH2-terminal Kinase Activation Leads to a FADD-dependent but Fas Ligand-independent Cell Death in Jurkat T Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Modulation of cell death by Bcl-XL through caspase interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Prevention of apoptosis by a baculovirus gene during infection of insect cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Aspartyl alpha-((diphenylphosphinyl)oxy)methyl ketones as novel inhibitors of interleukin-1 beta converting enzyme. Utility of the diphenylphosphinic acid leaving group for the inhibition of cysteine proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

RAIDD is a new 'death' adaptor molecule

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

1 reference

7 January 2021

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Genetic control of programmed cell death in the nematode C. elegans.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Involvement of an ICE-like protease in Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-beta -D-arabinofuranosylcytosine and other genotoxic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase 3 activity is required for skeletal muscle differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Human caspase 12 has acquired deleterious mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inhibition of ICE slows ALS in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Prevention of vertebrate neuronal death by the crmA gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inhibition of human caspases by peptide-based and macromolecular inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Need for caspase-2 in apoptosis of growth-factor-deprived PC12 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-14 is a novel developmentally regulated protease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inhibition of death receptor signals by cellular FLIP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

T cell-specific FADD-deficient mice: FADD is required for early T cell development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-independent cell killing by Fas-associated protein with death domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Evidence that caspase-13 is not a human but a bovine gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

DEDD regulates degradation of intermediate filaments during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Activation of caspase-2 in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Deciphering the pathways of life and death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Programmed cell death—IV. The influence of drugs on the breakdown of the intersegmental muscles of silkmoths

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Necrotic death pathway in Fas receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Fas receptor and neuronal cell death after spinal cord ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

An induced proximity model for caspase-8 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

From bench to clinic with apoptosis-based therapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Programmed cell death of developing mammalian neurons after genetic deletion of caspases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inactivating mutations of the caspase-10 gene in gastric cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apoptosis-associated proteolysis of vimentin in human prostate epithelial tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Lamin proteolysis facilitates nuclear events during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Dimer formation drives the activation of the cell death protease caspase 9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Crystal structure of the apoptotic suppressor CrmA in its cleaved form

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Structural basis for the activation of human procaspase-7

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Mechanism-based inactivation of caspases by the apoptotic suppressor p35.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Polyglutamine pathogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase inhibitors in prevention of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase activation: the induced-proximity model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The role of c-FLIP in modulation of CD95-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Signaling through focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cathepsin B-mediated activation of the proinflammatory caspase-11.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Oligomerization and activation of caspase-9, induced by Apaf-1 CARD.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-9 can be activated without proteolytic processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Biochemical characteristics of caspases-3, -6, -7, and -8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-2 mediates neuronal cell death induced by beta-amyloid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-10 is an initiator caspase in death receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

JOINTLESS is a MADS-box gene controlling tomato flower abscission zone development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cleavage of focal adhesion kinase by caspases during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Structure and mechanism of interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Cell death: the significance of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase activation is required for terminal erythroid differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207107

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207107

1 reference

9 August 2017

1 reference

PubMed ID

14634618