Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models (Q24306326)

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20 February 2020

title

Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models (English)

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3

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Hiromichi Ebi

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Anurag Singh

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Kwok Kin Wong

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Mari Mino-Kenudson

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Dora Dias-Santagata

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Jeffrey A Engelman

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Ryan B Corcoran

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Jeffrey Settleman

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Patricia Greninger

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author name string

Katherine A Cheng

2

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Anthony C Faber

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Erin M Coffee

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Ronald D Brown

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Jason T Godfrey

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Travis J Cohoon

10

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Youngchul Song

11

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Eugene Lifshits

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Kenneth E Hung

13

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Toshi Shioda

14

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Cyril H Benes

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language of work or name

English

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publication date

13 December 2012

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volume

23

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page(s)

121-128

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issue

1

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

20 February 2020

cites work

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

19 March 2017

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

19 March 2017

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

19 March 2017

1 reference

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The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

19 March 2017

1 reference

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

19 March 2017

1 reference

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

19 March 2017

1 reference

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Systematic identification of genomic markers of drug sensitivity in cancer cells

19 March 2017

1 reference

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

7 April 2017

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

7 April 2017

1 reference

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TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

7 April 2017

1 reference

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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

27 September 2017

1 reference

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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

27 September 2017

1 reference

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

27 September 2017

1 reference

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

27 September 2017

1 reference

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The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

27 September 2017

1 reference

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Ras signaling and therapies

27 September 2017

1 reference

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

27 September 2017

1 reference

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

27 September 2017

1 reference

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Targeting the RAF-MEK-ERK pathway in cancer therapy

27 September 2017

1 reference

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Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

27 September 2017

1 reference

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

27 September 2017

1 reference

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

27 September 2017

1 reference

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RAS oncogenes: the first 30 years.

27 September 2017

1 reference

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

29 November 2018

1 reference

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10.1016/J.CCR.2012.11.007

29 November 2018

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DOI

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