mTOR in Brain Physiology and Pathologies (Q38565769)

4 September 2017

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title

mTOR in Brain Physiology and Pathologies (English)

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4 September 2017

Joël Bockaert

1

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PubMed ID

26269525

4 September 2017

Philippe Marin

series ordinal

2

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4 September 2017

1 October 2015

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4 September 2017

Physiological Reviews

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4 September 2017

95

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4 September 2017

1157-1187

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4 September 2017

4

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Getting ready for building: signaling and autophagosome biogenesis.

4 September 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin inhibits the growth of glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mutations causing syndromic autism define an axis of synaptic pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Attenuation of Rhes activity significantly delays the appearance of behavioral symptoms in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Neuroanatomic observations of the brain in autism: a review and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

TSC on the peroxisome controls mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR signaling contributes to motor skill learning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The TOR pathway: a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Gangliogliomas: an intriguing tumor entity associated with focal epilepsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Localization of Rheb to the endomembrane is critical for its signaling function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Targeting the endocannabinoid system in the treatment of fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Time-restricted role for dendritic activation of the mTOR-p70 S6K pathway in the induction of late-phase long-term potentiation in the CA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

What are the indications for the use of a lumbar corset in low back pain?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Hypothalamic mTOR signaling regulates food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mutations in DEPDC5 cause familial focal epilepsy with variable foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Signaling pathways underlying the rapid antidepressant actions of ketamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of TOR by small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

From genes to cognition in tuberous sclerosis: implications for mTOR inhibitor-based treatment approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

PTEN signaling in brain: neuropathology and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The late endosome is essential for mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Hemimegalencephaly: part 2. Neuropathology suggests a disorder of cellular lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Influence of mTOR in energy and metabolic homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The trouble with spines in fragile X syndrome: density, maturity and plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR signaling: at the crossroads of plasticity, memory and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTORC2 controls actin polymerization required for consolidation of long-term memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTORC1 signaling controls multiple steps in ribosome biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Overexpression of s6 kinase 1 in brain tumours is associated with induction of hypoxia-responsive genes and predicts patients' survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR Hyperactivation in down syndrome hippocampus appears early during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Autophagy pathways in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Sirolimus is associated with new-onset diabetes in kidney transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Refractory epilepsy: mechanisms and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Immunosuppression using the mammalian target of rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Functional effects of a pathogenic mutation in Cereblon (CRBN) on the regulation of protein synthesis via the AMPK-mTOR cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Glutamatergic regulation of the p70S6 kinase in primary mouse neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Betulin inhibits lung carcinoma proliferation through activation of AMPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Focal malformations of cortical development: new vistas for molecular pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Review series: TOR kinase complexes and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Akt and mTOR mediate programmed necrosis in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The mTOR signaling pathway regulates pain-related synaptic plasticity in rat entorhinal-hippocampal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Metformin therapy in a transgenic mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR signaling in neural stem cells: from basic biology to disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Hemimegalencephaly: a fetal case with neuropathological confirmation and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Synaptic plasticity in depression: molecular, cellular and functional correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rheb regulates mitophagy induced by mitochondrial energetic status

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Critical role for hypothalamic mTOR activity in energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin extends murine lifespan but has limited effects on aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Autophagy in neurodegenerative disease: friend, foe or turncoat?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The role of autophagy in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Axonal protein synthesis and the regulation of primary afferent function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Caveat mTOR: aberrant signaling disrupts corticogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Novel translational control in Arc-dependent long term potentiation consolidation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of TFEB and V-ATPases by mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Lost in the jungle: new hurdles for optic nerve axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Somatic activation of AKT3 causes hemispheric developmental brain malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Coordination of circadian timing in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Metabolic control of puberty onset: new players, new mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Auditory processing in fragile x syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

An emerging role for TOR signaling in mammalian tissue and stem cell physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Differential cellular gene expression in ganglioglioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dysregulation of mTOR signaling in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Association of the small GTPase Rheb with the NMDA receptor subunit NR3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR signaling and its roles in normal and abnormal brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A unifying model for mTORC1-mediated regulation of mRNA translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR/PRAS40 interaction: hypertrophy or proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A role for the mTOR pathway in surface expression of AMPA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Minireview: Nutrient sensing by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Role of PRAS40 in Akt and mTOR signaling in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR kinase structure, mechanism and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Ezh2 regulates adult hippocampal neurogenesis and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Coordinated regulation of protein synthesis and degradation by mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Activation of mTORC2 by association with the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

Rheb1 is required for mTORC1 and myelination in postnatal brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00038.2014

10.1152/PHYSREV.00038.2014

21 January 2018

Identifiers

DOI

1 reference

4 September 2017

1 reference

PubMed ID

26269525