mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels. (Q33620587)

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English	mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels.	scientific article

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6 March 2020

mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels (English)

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6 March 2020

nucleus accumbens

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6 March 2020

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6 March 2020

Christopher V Dayas

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6 March 2020

author name string

Emily M Levi

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6 March 2020

Janine L Charnley

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6 March 2020

Doug W Smith

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6 March 2020

Phillip W Dickson

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28 January 2014

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6 March 2020

Neuropsychopharmacology

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39

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6 March 2020

1694-1702

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6 March 2020

https://scigraph.springernature.com/pub.10.1038/npp.2014.16

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Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

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21 June 2018

mTORC2 controls actin polymerization required for consolidation of long-term memory.

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21 June 2018

An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction

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21 June 2018

Mechanisms of CaMKII action in long-term potentiation

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21 June 2018

Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization

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21 June 2018

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

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21 June 2018

Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving

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21 June 2018

Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders

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21 June 2018

Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour

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21 June 2018

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin

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21 June 2018

The Bermuda Triangle of cocaine-induced neuroadaptations

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21 June 2018

Transition to addiction is associated with a persistent impairment in synaptic plasticity

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21 June 2018

Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement.

1 reference

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21 June 2018

mTOR signaling: at the crossroads of plasticity, memory and disease

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21 June 2018

BDNF activates mTOR to regulate GluR1 expression required for memory formation

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21 June 2018

Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats.

1 reference

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21 June 2018

Neurotrophic factors and structural plasticity in addiction

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21 June 2018

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

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21 June 2018

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

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21 June 2018

Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons

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21 June 2018

Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation

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21 June 2018

Regulation of psychostimulant-induced signaling and gene expression in the striatum

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21 June 2018

Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats

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21 June 2018

Time-restricted role for dendritic activation of the mTOR-p70 S6K pathway in the induction of late-phase long-term potentiation in the CA1

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21 June 2018

The roles of calcium/calmodulin-dependent and Ras/mitogen-activated protein kinases in the development of psychostimulant-induced behavioral sensitization.

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21 June 2018

Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine

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21 June 2018

CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking

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21 January 2018

Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals.

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21 January 2018

Evidence for addiction-like behavior in the rat.

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21 January 2018

Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

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21 January 2018

Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei.

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21 January 2018

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.

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21 January 2018

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats.

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Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area.

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21 January 2018

Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

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21 January 2018

BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development.

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21 January 2018

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Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats.

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Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.

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30 October 2018

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10.1038/NPP.2014.16

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6 March 2020

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6 March 2020

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