TOR, a central controller of cell growth (Q27933354)

PubMed

11057898

1 December 2016

title

TOR, a central controller of cell growth (English)

1 reference

PubMed

1 December 2016

1 reference

T Schmelzle

1

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M N Hall

series ordinal

2

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publication date

13 October 2000

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language of work or name

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1 reference

11057898

publication type of scholarly work

1 December 2016

volume

103

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issue

2

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page(s)

253-62

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review article

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Europe PubMed Central

cites work

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TOR controls translation initiation and early G1 progression in yeast

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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

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Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast

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Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

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The 14-3-3 proteins positively regulate rapamycin-sensitive signaling

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

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FAT: a novel domain in PIK-related kinases

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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7 January 2021

The TOR signaling cascade regulates gene expression in response to nutrients

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7 January 2021

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

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7 January 2021

α4 Associates with Protein Phosphatases 2A, 4, and 6

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7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

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7 January 2021

Size control in animal development

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7 January 2021

Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.

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7 January 2021

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

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7 January 2021

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

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7 January 2021

From small flies come big discoveries about size control

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7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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7 January 2021

Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity

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7 January 2021

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

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7 January 2021

Regulation of eIF-4E BP1 phosphorylation by mTOR.

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7 January 2021

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

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7 January 2021

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

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7 January 2021

Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast

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7 January 2021

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

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7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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7 January 2021

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton

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7 January 2021

Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

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7 January 2021

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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7 January 2021

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

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7 January 2021

Drosophila myc regulates cellular growth during development

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7 January 2021

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7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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7 January 2021

Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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7 January 2021

Perspectives: cell biology. All creatures great and small

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7 January 2021

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1 reference

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7 January 2021

Rapamycin resistance tied to defective regulation of p27Kip1.

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7 January 2021

Modulation of transcription of rRNA genes by rapamycin

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7 January 2021

A protein conjugation system essential for autophagy

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7 January 2021

Drosophila S6 kinase: a regulator of cell size

1 reference

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7 January 2021

B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Regulation of Protein Phosphatase 2A Catalytic Activity by alpha4 Protein and Its Yeast Homolog Tap42

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Connections between growth and the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Multiple pathways control protein kinase C phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Ras1 promotes cellular growth in the Drosophila wing

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The modular phosphorylation and activation of p70s6k.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The role of c-myc in cellular growth control

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

TOR2 is required for organization of the actin cytoskeleton in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

TOR signalling and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The economics of ribosome biosynthesis in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

The genetic control of organ growth: insights from Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Rapamycin Induces the G0 Program of Transcriptional Repression in Yeast by Interfering with the TOR Signaling Pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3

7 January 2021

10.1016/S0092-8674(00)00117-3

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

11057898

1 reference

Consolidated OpenCitations Corpus – April 2017