GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway (Q28569842)

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Amelioration of protein misfolding disease by rapamycin: translation or autophagy?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Growing roles for the mTOR pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

The amino acid sensitive TOR pathway from yeast to mammals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Interaction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Stress-induced gene expression requires programmed recovery from translational repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Downregulation of NF-kappaB signaling by mutant huntingtin proteins induces oxidative stress and cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Akt up- and down-regulation in response to endoplasmic reticulum stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Autophagy in the Pathogenesis of Disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Ischaemic preconditioning in the rat brain: effect on the activity of several initiation factors, Akt and extracellular signal-regulated protein kinase phosphorylation, and GRP78 and GADD34 expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Autophagy is activated for cell survival after endoplasmic reticulum stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.020