Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia (Q43099344)

13 November 2017

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia (English)

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13 November 2017

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Gabriella D'Arcangelo

5

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13 November 2017

M Cecilia Ljungberg

1

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13 November 2017

C Nicole Sunnen

2

1 reference

13 November 2017

Joaquin N Lugo

3

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13 November 2017

Anne E Anderson

4

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13 November 2017

26 May 2009

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Disease Models & Mechanisms

13 November 2017

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13 November 2017

2

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13 November 2017

7-8

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13 November 2017

389-398

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describes a project that uses

13 November 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2707106/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

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Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons

25 May 2018

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A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice

25 May 2018

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Tuberous sclerosis complex and epilepsy: recent developments and future challenges

25 May 2018

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Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis.

25 May 2018

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Pten regulates neuronal arborization and social interaction in mice

25 May 2018

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Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

25 May 2018

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PTEN function in normal and neoplastic growth

25 May 2018

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Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

25 May 2018

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

25 May 2018

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Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

25 May 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

25 May 2018

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Insulin signaling pathways in cortical dysplasia and TSC-tubers: tissue microarray analysis.

25 May 2018

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25 May 2018

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mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

25 May 2018

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PTEN: one gene, many syndromes

25 May 2018

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PTEN function in mammalian cell size regulation

25 May 2018

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PTEN mutation in a family with Cowden syndrome and autism

25 May 2018

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Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes

25 May 2018

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Signalling through phosphoinositide 3-kinases: the lipids take centre stage

25 May 2018

1 reference

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

25 May 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

25 May 2018

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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

25 May 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

25 May 2018

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

25 May 2018

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Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.

25 May 2018

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Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia.

15 August 2018

1 reference

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Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

15 August 2018

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Autism and epilepsy: cause, consequence, comorbidity, or coincidence?

15 August 2018

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Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo

15 August 2018

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mTOR cascade activation distinguishes tubers from focal cortical dysplasia

15 August 2018

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Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

15 August 2018

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Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

15 August 2018

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Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

15 August 2018

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Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

15 August 2018

1 reference

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Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.

15 August 2018

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

15 August 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19470613

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/DMM.002386

1 reference

13 November 2017

1 reference

13 November 2017

1 reference