Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations (Q28506710)

GOA release 2020-03-11

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13

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Marta Martinez-Vicente

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David Westaway

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Ju-hyun Lee

object named as

Ju-Hyun Lee

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author name string

W. Haung Yu

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24 January 2017

Asok Kumar

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24 January 2017

Sooyeon Lee

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24 January 2017

Panaiyur S. Mohan

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24 January 2017

Corrinne M. Peterhoff

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24 January 2017

Devin M. Wolfe

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24 January 2017

Ashish C. Massey

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24 January 2017

Guy Sovak

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24 January 2017

Yasuo Uchiyama

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24 January 2017

Ralph A. Nixon

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24 January 2017

language of work or name

English

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publication date

25 June 2010

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24 January 2017

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24 January 2017

141

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1146–1158

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24 January 2017

ImageJ

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3647462/fullTextXML

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ScienceSource

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cites work

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Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

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Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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29 September 2017

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29 September 2017

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Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

29 September 2017

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29 September 2017

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Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

29 September 2017

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29 September 2017

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29 September 2017

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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

29 September 2017

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29 September 2017

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29 September 2017

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Presenilins and Alzheimer's disease

29 September 2017

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2 June 2018

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Differential segregation of human and hamster cathepsin D in transfected baby-hamster kidney cells

2 June 2018

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The vacuolar H(+)-translocating ATPase of renal tubules contains a 115-kDa glycosylated subunit

2 June 2018

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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

2 June 2018

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Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.

27 November 2018

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gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

27 November 2018

1 reference

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Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

27 November 2018

1 reference

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Effects of PS1 deficiency on membrane protein trafficking in neurons.

27 November 2018

1 reference

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Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells

27 November 2018

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12 December 2020

Regulation of intracellular protein degradation in IMR-90 human diploid fibroblasts

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12 December 2020

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

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12 December 2020

Subcellular distribution and turnover of presenilins in transfected cells

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12 December 2020

Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase

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12 December 2020

10.1016/J.CELL.2010.05.008

Identifiers

DOI

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1340307

1340307

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