Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. (Q45923687)

17 December 2017

title

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. (English)

1 reference

17 December 2017

1 reference

1 reference

3

Paul Greengard

1 reference

17 December 2017

Emmanuel Valjent

4

0 references

Myriam Heiman

series ordinal

2

object named as

Myriam Heiman

1 reference

17 December 2017

author name string

Emanuela Santini

series ordinal

1

1 reference

17 December 2017

Gilberto Fisone

series ordinal

5

1 reference

17 December 2017

publication date

21 July 2009

1 reference

17 December 2017

published in

Science Signaling

1 reference

17 December 2017

volume

2

1 reference

17 December 2017

issue

80

1 reference

17 December 2017

page(s)

ra36

1 reference

17 December 2017

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE02033

L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Inhibitors of the mammalian target of rapamycin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

The modular phosphorylation and activation of p70s6k.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Parkinson's disease: levodopa-induced dyskinesia and signal transduction.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Rheb binds and regulates the mTOR kinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson's disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

A 6-hydroxydopamine-induced selective parkinsonian rat model

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Translational control of long-lasting synaptic plasticity and memory

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

MAPK cascade signalling and synaptic plasticity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCISIGNAL.2000308

Identifiers

DOI

10.1126/SCISIGNAL.2000308

1 reference

17 December 2017

PubMed ID

19622833

1 reference

17 December 2017