Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease (Q33700331)

28 July 2017

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease (English)

1 reference

28 July 2017

0 references

1 reference

Gunnar K Gouras

10

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author name string

Tao Ma

1

1 reference

28 July 2017

Charles A Hoeffer

2

1 reference

28 July 2017

Estibaliz Capetillo-Zarate

3

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28 July 2017

Fangmin Yu

4

1 reference

28 July 2017

Helen Wong

5

1 reference

28 July 2017

Michael T Lin

6

1 reference

28 July 2017

Davide Tampellini

7

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28 July 2017

Eric Klann

8

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28 July 2017

Robert D Blitzer

9

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28 July 2017

language of work or name

English

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publication date

20 September 2010

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28 July 2017

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28 July 2017

5

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28 July 2017

9

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Creative Commons Attribution 4.0 International

28 July 2017

start time

20 September 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

21 June 2018

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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

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Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

21 June 2018

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The role of GSK-3 in synaptic plasticity.

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Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 June 2018

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Stress and mTORture signaling

21 June 2018

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Dendritic protein synthesis, synaptic plasticity, and memory

21 June 2018

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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Mind the GAP: Wnt steps onto the mTORC1 train

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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

21 June 2018

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mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

21 June 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 June 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 June 2018

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Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

21 June 2018

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Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 June 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 June 2018

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beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 June 2018

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The role of calcium in neuromuscular facilitation

21 June 2018

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

21 June 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012845

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

21 January 2018

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Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

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Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

21 January 2018

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Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012845

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012845

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

21 January 2018

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Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

21 January 2018

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10.1371/JOURNAL.PONE.0012845

30 October 2018

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DOI

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28 July 2017

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28 July 2017

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