Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases (Q33613123)

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English	Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases	scientific article

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scholarly article

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Europe PubMed Central

28 July 2017

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases (English)

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Europe PubMed Central

28 July 2017

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Parkinson's disease

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Edward Rockenstein

4

object named as

Edward Rockenstein

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Europe PubMed Central

28 July 2017

Eliezer Masliah

9

object named as

Eliezer Masliah

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Europe PubMed Central

28 July 2017

Tony Wyss-Coray

8

object named as

Tony Wyss-Coray

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Europe PubMed Central

28 July 2017

author name string

Brian Spencer

1

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Europe PubMed Central

28 July 2017

Rewati Potkar

2

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Europe PubMed Central

28 July 2017

Margarita Trejo

3

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Europe PubMed Central

28 July 2017

Christina Patrick

5

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Europe PubMed Central

28 July 2017

Ryan Gindi

6

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28 July 2017

Anthony Adame

7

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28 July 2017

language of work or name

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publication date

1 October 2009

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28 July 2017

Journal of Neuroscience

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Europe PubMed Central

28 July 2017

29

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28 July 2017

13578-13588

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Europe PubMed Central

28 July 2017

43

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Europe PubMed Central

28 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2812014/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2812014/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Ambra1 regulates autophagy and development of the nervous system

1 reference

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14 July 2018

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

1 reference

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14 July 2018

Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein

1 reference

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14 July 2018

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

1 reference

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14 July 2018

The mTOR pathway in the control of protein synthesis

1 reference

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14 July 2018

Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans

1 reference

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14 July 2018

Alpha-synuclein-positive structures induced in leupeptin-infused rats

1 reference

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14 July 2018

The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons.

1 reference

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14 July 2018

Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

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14 July 2018

Regulation and role of autophagy in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Autophagy: molecular mechanisms, physiological functions and relevance in human pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Autophagy: in sickness and in health

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases

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14 July 2018

Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies

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14 July 2018

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

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14 July 2018

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

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14 July 2018

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein

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14 July 2018

Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia.

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14 July 2018

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812014

14 July 2018

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

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14 July 2018

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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14 July 2018

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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14 July 2018

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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14 July 2018

Is green fluorescent protein toxic to the living cells?

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14 July 2018

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

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14 July 2018

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

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14 July 2018

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

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14 July 2018

Alpha-synuclein in Lewy bodies

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14 July 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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14 July 2018

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

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14 July 2018

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Lewy body disease

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14 July 2018

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Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

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Neurodegeneration induces upregulation of Beclin 1.

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30 October 2018

Rapamycin alleviates toxicity of different aggregate-prone proteins

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30 October 2018

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

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30 October 2018

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

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30 October 2018

Involvement of macroautophagy in the dissolution of neuronal inclusions.

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30 October 2018

Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease

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30 October 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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30 October 2018

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

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30 October 2018

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

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Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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30 October 2018

Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment

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Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

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Gaucher disease and parkinsonism: a phenotypic and genotypic characterization

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Gaucher disease associated with parkinsonism: four further case reports

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Identifiers

10.1523/JNEUROSCI.4390-09.2009

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Europe PubMed Central

28 July 2017

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Europe PubMed Central

28 July 2017

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Europe PubMed Central

28 July 2017

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