Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. (Q38841261)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27211488%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

review article

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title

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers (English)

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2 April 2020

1

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2 April 2020

author name string

Simon Bekker-Jensen

series ordinal

2

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2 April 2020

Niels Mailand

series ordinal

3

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2 April 2020

publication date

1 May 2016

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Nature Reviews Molecular Cell Biology

2 April 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27211488%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

volume

17

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2 April 2020

issue

6

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2 April 2020

page(s)

379-394

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https://scigraph.springernature.com/pub.10.1038/nrm.2016.58

2 April 2020

exact match

0 references

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

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RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage.

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Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

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Specification of SUMO1- and SUMO2-interacting motifs

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Assembly and function of DNA double-strand break repair foci in mammalian cells

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

31 March 2020

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RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

31 March 2020

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A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

31 March 2020

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The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

31 March 2020

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Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

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Regulation of PCNA-protein interactions for genome stability

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DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

31 March 2020

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RAD18 transmits DNA damage signalling to elicit homologous recombination repair

31 March 2020

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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

31 March 2020

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Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage

31 March 2020

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A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

31 March 2020

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31 March 2020

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31 March 2020

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BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

31 March 2020

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Monoubiquitination of H2AX protein regulates DNA damage response signaling

31 March 2020

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CHFR is important for the first wave of ubiquitination at DNA damage sites

31 March 2020

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

31 March 2020

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PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry

31 March 2020

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RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks

31 March 2020

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The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

31 March 2020

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Push back to respond better: regulatory inhibition of the DNA double-strand break response

31 March 2020

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TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

31 March 2020

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Human USP3 is a chromatin modifier required for S phase progression and genome stability

31 March 2020

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The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

31 March 2020

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USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

31 March 2020

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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

31 March 2020

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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

31 March 2020

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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

31 March 2020

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The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

31 March 2020

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Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice

31 March 2020

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The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

31 March 2020

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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

31 March 2020

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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

31 March 2020

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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

31 March 2020

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DNA damage signaling in response to double-strand breaks during mitosis

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Mitosis inhibits DNA double-strand break repair to guard against telomere fusions

31 March 2020

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DNA-damage response and repair activities at uncapped telomeres depend on RNF8

31 March 2020

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A two-step mechanism for TRF2-mediated chromosome-end protection

31 March 2020

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Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

31 March 2020

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APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.

31 March 2020

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The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

31 March 2020

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An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation

31 March 2020

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USP4 Auto-Deubiquitylation Promotes Homologous Recombination

31 March 2020

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The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection.

31 March 2020

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

31 March 2020

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Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

31 March 2020

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

31 March 2020

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Histone ubiquitination associates with BRCA1-dependent DNA damage response

31 March 2020

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Double-strand break repair: 53BP1 comes into focus

31 March 2020

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Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle

31 March 2020

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RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

31 March 2020

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A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

31 March 2020

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

31 March 2020

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

31 March 2020

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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

31 March 2020

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RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

31 March 2020

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Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

31 March 2020

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53BP1 regulates DSB repair using Rif1 to control 5' end resection

31 March 2020

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MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection

31 March 2020

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REV7 counteracts DNA double-strand break resection and affects PARP inhibition

31 March 2020

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Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

31 March 2020

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BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

31 March 2020

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Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

31 March 2020

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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

31 March 2020

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PTIP associates with Artemis to dictate DNA repair pathway choice

31 March 2020

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The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

31 March 2020

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CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

31 March 2020

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BRCA1 accelerates CtIP-mediated DNA-end resection

31 March 2020

1 reference

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The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection

31 March 2020

1 reference

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

31 March 2020

1 reference

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BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

31 March 2020

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BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.58

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

BRCA1 is a histone-H2A-specific ubiquitin ligase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

A mechanism for the suppression of homologous recombination in G1 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Sumoylation of MDC1 is important for proper DNA damage response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

SUMO modification regulates BLM and RAD51 interaction at damaged replication forks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

31 March 2020

1 reference

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RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.58

RNF111-dependent neddylation activates DNA damage-induced ubiquitination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Protein neddylation: beyond cullin-RING ligases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Cancer treatment according to BRCA1 and BRCA2 mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RNF4 is required for DNA double-strand break repair in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

53BP1 is required for class switch recombination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Ubiquitination in disease pathogenesis and treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

RNA-guided human genome engineering via Cas9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Multiplex genome engineering using CRISPR/Cas systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Genome-scale CRISPR-Cas9 knockout screening in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58

Genetic screens in human cells using the CRISPR-Cas9 system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.58