TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes (Q24295574)

Thyroid hormone receptor interactor 12

GOA release 2020-03-11

1 reference

negative regulation of double-strand break repair

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

13

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Jiří Bártek

16

Jiri Bartek

0 references

Jiří Lukáš

17

Jiri Lukas

0 references

Thorkell Gudjonsson

Thorkell Gudjonsson

1

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Velibor Savic

Velibor Savic

3

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Luis Ignacio Toledo

Luis Toledo

4

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Beate Neumann

Beate Neumann

12

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Simon Bekker-Jensen

Simon Bekker-Jensen

10

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Darren N Saunders

Darren Saunders

15

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Claudia Lukas

Claudia Lukas

18

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Matthias Altmeyer

Matthias Altmeyer

2

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Jiřina Bártková

7

Jirina Bartkova

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author name string

Christoffel Dinant

5

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Merete Grøfte

6

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Maria Poulsen

8

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Yasuyoshi Oka

9

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Niels Mailand

11

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Robert Shearer

The N‐end rule pathway and regulation by proteolysis

14

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publication date

17 August 2012

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language of work or name

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150

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issue

4

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page(s)

697-709

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cites work

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Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation

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TRIP12 functions as an E3 ubiquitin ligase of APP-BP1

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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

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53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

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Human USP3 is a chromatin modifier required for S phase progression and genome stability

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The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

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A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

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Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

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BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

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Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

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A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

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7 January 2021

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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Human CtIP promotes DNA end resection

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Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

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Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

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Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

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The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

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7 January 2021

DNA-damage response and repair activities at uncapped telomeres depend on RNF8

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

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Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

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The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

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EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer

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DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

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Spatial and temporal organization of replicating Escherichia coli chromosomes

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The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

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Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

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Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex

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The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection

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EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response

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EDD mediates DNA damage-induced activation of CHK2

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

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Replication stress induces 53BP1-containing OPT domains in G1 cells

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7 January 2021

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

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53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

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Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

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Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis

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Development and use of fluorescent protein markers in living cells

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UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

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7 January 2021

Identification of mammalian protein quality control factors by high-throughput cellular imaging

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7 January 2021

The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints

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