Ubiquitination in disease pathogenesis and treatment (Q38265657)

1 September 2017

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title

Ubiquitination in disease pathogenesis and treatment (English)

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1 September 2017

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protein ubiquitination

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3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Doris Popovic

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Domagoj Vucic

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

English

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publication date

6 November 2014

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1 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

20

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

1242-1253

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375928%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nm.3739

8 June 2020

exact match

0 references

1 reference

The spatial and temporal organization of ubiquitin networks

21 January 2018

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Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

21 January 2018

1 reference

Targeting the ubiquitin system in cancer therapy

21 January 2018

1 reference

A phase 2 study of bortezomib in relapsed, refractory myeloma

21 January 2018

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RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

21 January 2018

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Ubiquitin networks in cancer

21 January 2018

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MDM2, MDMX and p53 in oncogenesis and cancer therapy

21 January 2018

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

21 January 2018

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Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

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The Cbl interactome and its functions

21 January 2018

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Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

21 January 2018

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A20: from ubiquitin editing to tumour suppression

21 January 2018

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Identification of the familial cylindromatosis tumour-suppressor gene

21 January 2018

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Loss of the tumor suppressor BAP1 causes myeloid transformation

21 January 2018

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USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

21 January 2018

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Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

21 January 2018

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CYLD: a deubiquitination enzyme with multiple roles in cancer.

21 January 2018

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[CYLD deubiquitinase as a recurrent target in oncogenic processes].

21 January 2018

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Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination

21 January 2018

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H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation

21 January 2018

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Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

21 January 2018

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Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

21 January 2018

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IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

21 January 2018

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Inflammation meets cancer, with NF-κB as the matchmaker

21 January 2018

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

21 January 2018

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

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Classical and/or alternative NF-kappaB pathway activation in multiple myeloma

21 January 2018

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The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.

21 January 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

21 January 2018

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Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

21 January 2018

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The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair

21 January 2018

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

21 January 2018

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FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair

21 January 2018

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DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

21 January 2018

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RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

21 January 2018

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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

21 January 2018

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USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

21 January 2018

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The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

21 January 2018

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Molecular nature of radiation injury and DNA repair disorders associated with radiosensitivity.

21 January 2018

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

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DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome

21 January 2018

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

21 January 2018

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Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

21 January 2018

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Autophagy-deficient mice develop multiple liver tumors

21 January 2018

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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

21 January 2018

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Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

21 January 2018

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Deconvoluting the context-dependent role for autophagy in cancer

21 January 2018

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Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs

21 January 2018

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Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

21 January 2018

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

21 January 2018

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Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

21 January 2018

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Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

21 January 2018

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p53 status determines the role of autophagy in pancreatic tumour development

21 January 2018

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Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma)

21 January 2018

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A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations

21 January 2018

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Genetic lessons learned from X-linked Mendelian susceptibility to mycobacterial diseases

21 January 2018

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

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Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

21 January 2018

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Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

21 January 2018

1 reference

21 January 2018

1 reference

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

21 January 2018

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

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Ubiquitin in inflammation: the right linkage makes all the difference

21 January 2018

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Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

21 January 2018

1 reference

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

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Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

21 January 2018

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Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

21 January 2018

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Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation

21 January 2018

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A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

21 January 2018

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PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria

21 January 2018

1 reference

Mitophagy: a complex mechanism of mitochondrial removal

21 January 2018

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Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

21 January 2018

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

21 January 2018

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

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The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

21 January 2018

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The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

21 January 2018

1 reference

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism

21 January 2018

1 reference

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

1 reference

Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins

21 January 2018

1 reference

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

21 January 2018

1 reference

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

21 January 2018

1 reference

Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy

21 January 2018

1 reference

Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.

21 January 2018

1 reference

Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

1 reference

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 January 2018

1 reference

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

21 January 2018

1 reference

Molecular mechanisms modulating muscle mass

21 January 2018

1 reference

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.

21 January 2018

1 reference

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

21 January 2018

1 reference

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

21 January 2018

1 reference

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

21 January 2018

1 reference

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo

21 January 2018

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Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

21 January 2018

1 reference

Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation

21 January 2018

1 reference

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

21 January 2018

1 reference

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

21 January 2018

1 reference

Chaperone-assisted selective autophagy is essential for muscle maintenance

21 January 2018

1 reference

From mice to men: insights into the insulin resistance syndromes

21 January 2018

1 reference

IRS proteins and the common path to diabetes

21 January 2018

1 reference

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

Type 2 diabetes as an inflammatory disease

21 January 2018

1 reference

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

21 January 2018

1 reference

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

21 January 2018

1 reference

Nontraditional cytotoxic therapies for relapsed/refractory multiple myeloma

21 January 2018

1 reference

Hematologic malignancies: new developments and future treatments

21 January 2018

1 reference

New proteasome inhibitors in myeloma

21 January 2018

1 reference

Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

21 January 2018

1 reference

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

21 January 2018

1 reference

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

21 January 2018

1 reference

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

21 January 2018

1 reference

The immunoproteasome: an emerging therapeutic target

21 January 2018

1 reference

Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.

21 January 2018

1 reference

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

21 January 2018

1 reference

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

21 January 2018

1 reference

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

21 January 2018

1 reference

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

E2s: structurally economical and functionally replete

21 January 2018

1 reference

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

21 January 2018

1 reference

Assembly of k11-linked ubiquitin chains by the anaphase-promoting complex.

21 January 2018

1 reference

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

21 January 2018

1 reference

Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

21 January 2018

1 reference

RING domain E3 ubiquitin ligases

21 January 2018

1 reference

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

21 January 2018

1 reference

Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy

21 January 2018

1 reference

HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

21 January 2018

1 reference

Targeting IAP proteins for therapeutic intervention in cancer

21 January 2018

1 reference

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

1 reference

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics

21 January 2018

1 reference

Skp2 is a promising therapeutic target in breast cancer

21 January 2018

1 reference

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

21 January 2018

1 reference

Structure of parkin reveals mechanisms for ubiquitin ligase activation

21 January 2018

1 reference

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

21 January 2018

1 reference

Deubiquitinases in cancer: new functions and therapeutic options.

21 January 2018

1 reference

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

21 January 2018

1 reference

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

21 January 2018

1 reference

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

21 January 2018

1 reference

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

21 January 2018

1 reference

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

21 January 2018

1 reference

Generation and physiological roles of linear ubiquitin chains

21 January 2018

1 reference

Deciphering Functions of Branched Ubiquitin Chains

21 January 2018

1 reference

Enhanced protein degradation by branched ubiquitin chains.

21 January 2018

1 reference

Autophagy modulation as a potential therapeutic target for diverse diseases

21 January 2018

1 reference

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

1 reference

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

1 reference

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms

21 January 2018

1 reference

A Strategy for Modulation of Enzymes in the Ubiquitin System

21 January 2018

1 reference

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

21 January 2018

1 reference

12 December 2020

Ubiquitin is phosphorylated by PINK1 to activate parkin

1 reference

12 December 2020

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

1 reference

12 December 2020

Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E

1 reference

12 December 2020

Regulation of insulin receptor kinase activity by endosomal processes: possible areas for therapeutic intervention.

1 reference

12 December 2020

IKK regulation and human genetics

1 reference

12 December 2020

Carfilzomib: a novel treatment in relapsed and refractory multiple myeloma

1 reference

12 December 2020

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

12 December 2020

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

1 reference

12 December 2020

Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas.

1 reference

12 December 2020