The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. (Q38094984)

28 August 2017

The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. (English)

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28 August 2017

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Sally Hunter

1

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Carol Brayne

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3

object named as

Carol Brayne

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28 August 2017

Thomas Arendt

2

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28 August 2017

3 April 2013

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28 August 2017

Molecular Neurobiology

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28 August 2017

48

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28 August 2017

556-570

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28 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s12035-013-8445-3

28 August 2017

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21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Exercise tames the wild side of the Myc network: a hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Applicability and effects of physical exercise on physical and cognitive functions and activities of daily living among people with dementia: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress and inflammation in brain aging: nutritional considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cognitive reserve and the neurobiology of cognitive aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Role of common and rare APP DNA sequence variants in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Apo E genotypes and risk of dementia in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Phenotype associated with APP duplication in five families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch and the p53 clan of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Implication of APP secretases in notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Alzheimer's disease and Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Do c-Jun, c-Fos, and amyloid precursor protein play a role in neuronal death or survival?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The ups and downs of Wnt signaling in prevalent neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Wnt signaling in Alzheimer's disease: up or down, that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Vital elements of the Wnt-Frizzled signaling pathway in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Wnt signaling in neuroprotection and stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A common biological mechanism in cancer and Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid precursor protein modulates beta-catenin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Variations in the neuropathology of familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch: from neural development to neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cholesterol in Alzheimer's disease: unresolved questions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Microglia and neuroprotection: from in vitro studies to therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Microglia: scapegoat, saboteur, or something else?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A second look into the oxidant mechanisms in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Copernicus revisited: amyloid beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Education, the brain and dementia: neuroprotection or compensation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Age and Histopathologic Heterogeneity in Alzheimer's Disease

21 January 2018

1 reference

12 December 2020

Amyloid-β peptide: Dr. Jekyll or Mr. Hyde?

1 reference

12 December 2020

Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study

1 reference

12 December 2020

The cholinergic pathology in Alzheimer's disease--discrepancies between clinical experience and pathophysiological findings

1 reference

12 December 2020

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

1 reference

12 December 2020

Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology

1 reference

12 December 2020

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease

1 reference

12 December 2020

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.

1 reference

12 December 2020

Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease

1 reference

12 December 2020

Pin1: a new genetic link between Alzheimer's disease, cancer and aging.

1 reference

12 December 2020

Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

12 December 2020

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease

1 reference

12 December 2020

Cholinesterase inhibitors for Alzheimer's disease

1 reference

12 December 2020

Correlates of response to acetylcholinesterase inhibitor therapy in Alzheimer's disease.

1 reference

12 December 2020

Induction of p21ras in Alzheimer pathology.

1 reference

12 December 2020

Memantine: a review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias.

1 reference

12 December 2020

Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system

1 reference

12 December 2020

Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type

1 reference

12 December 2020

Cortical tissue of patients with hereditary cerebral hemorrhage with amyloidosis (Dutch) contains various extracellular matrix deposits.

1 reference

12 December 2020

Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration

1 reference

12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

1 reference

12 December 2020

Altered immune responses in apolipoprotein E-deficient mice

1 reference

12 December 2020

Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.

1 reference

12 December 2020

Cross-talk between apolipoprotein E and cytokines

1 reference

12 December 2020

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder.

1 reference

12 December 2020

Beta amyloid angiogenic activity in vitro and in vivo.

1 reference

12 December 2020

Epigenetic mechanisms in Alzheimer's disease

1 reference

12 December 2020

The role of diet in cognitive decline

1 reference

12 December 2020

Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity?

1 reference

12 December 2020

A review: inflammatory process in Alzheimer's disease, role of cytokines.

1 reference

12 December 2020

An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain.

1 reference

12 December 2020

Pathogenic effects of D23N Iowa mutant amyloid beta -protein

1 reference

12 December 2020

The role and therapeutic potential of monocytic cells in Alzheimer's disease.

1 reference

12 December 2020

Assessing the toxicity of tau aggregation.

1 reference

12 December 2020

Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease

1 reference

12 December 2020

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

1 reference

12 December 2020

Genetic aspects of Alzheimer's disease.

1 reference

12 December 2020

Role of α7-nicotinic acetylcholine receptor in normal and cancer stem cells

1 reference

12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

1 reference

12 December 2020

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease.

1 reference

12 December 2020

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

1 reference

12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

12 December 2020

10.1007/S12035-013-8445-3

Identifiers

DOI

1 reference

PubMed ID

23546742

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23546742