Implication of APP secretases in notch signaling (Q34509767)

2 August 2017

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title

Implication of APP secretases in notch signaling (English)

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2 August 2017

D Hartmann

1

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2 August 2017

J Tournoy

2

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2 August 2017

P Saftig

3

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2 August 2017

W Annaert

4

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2 August 2017

B De Strooper

5

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2 August 2017

1 October 2001

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Journal of Molecular Neuroscience

2 August 2017

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2 August 2017

17

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2 August 2017

171-181

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2 August 2017

2

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https://scigraph.springernature.com/pub.10.1385/jmn:17:2:171

2 August 2017

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cites work

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

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12 December 2020

An essential role for ectodomain shedding in mammalian development

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12 December 2020

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1 reference

12 December 2020

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1 reference

12 December 2020

Mesp2 initiates somite segmentation through the Notch signalling pathway.

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12 December 2020

Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

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12 December 2020

Notch1 and T-cell development: insights from conditional knockout mice

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12 December 2020

The Notch ligand Jagged1 is required for inner ear sensory development.

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti

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12 December 2020

Gamma -secretase inhibitors repress thymocyte development

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12 December 2020

Calcium depletion dissociates and activates heterodimeric notch receptors

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12 December 2020

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries.

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12 December 2020

Secretases as therapeutic targets for the treatment of Alzheimer's disease

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12 December 2020

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

Notch1 is required for the coordinate segmentation of somites

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12 December 2020

Lack of requirement for presenilin1 in Notch1 signaling.

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12 December 2020

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

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12 December 2020

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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12 December 2020

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12 December 2020

Notch signaling: cell fate control and signal integration in development

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12 December 2020

An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).

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12 December 2020

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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12 December 2020

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

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12 December 2020

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Alzheimer's disease: genetic studies and transgenic models

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12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Where Notch and Wnt signaling meet. The presenilin hub

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12 December 2020

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

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12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

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12 December 2020

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

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12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

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12 December 2020

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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12 December 2020

Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Skin development: delta laid bare.

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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12 December 2020

Presenilin is required for activity and nuclear access of Notch in Drosophila

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12 December 2020

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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12 December 2020

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs

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12 December 2020

Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster

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12 December 2020

Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

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12 December 2020

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

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12 December 2020

Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients

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12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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12 December 2020

Ligand-induced signaling in the absence of furin processing of Notch1.

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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12 December 2020

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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12 December 2020

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

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12 December 2020

Processing of the notch ligand delta by the metalloprotease Kuzbanian

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12 December 2020

Notch signaling is essential for vascular morphogenesis in mice

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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12 December 2020

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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12 December 2020

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

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12 December 2020

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

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12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

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12 December 2020

Notch1 is essential for postimplantation development in mice.

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12 December 2020

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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12 December 2020

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

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12 December 2020

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

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12 December 2020

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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12 December 2020

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis.

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12 December 2020

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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12 December 2020

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

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12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

Proteolytic processing and cell biological functions of the amyloid precursor protein

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12 December 2020

Identifiers

DOI

10.1385/JMN:17:2:171

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Dimensions Publication ID

2 August 2017

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