Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease (Q35557675)

8 August 2017

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title

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease (English)

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8 August 2017

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Anne Eckert

1

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author name string

Uta Keil

2

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8 August 2017

Celio A Marques

3

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8 August 2017

Astrid Bonert

4

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8 August 2017

Claudia Frey

5

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8 August 2017

Katrin Schüssel

6

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8 August 2017

Walter E Müller

7

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8 August 2017

language of work or name

English

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publication date

1 October 2003

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8 August 2017

Biochemical Pharmacology

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8 August 2017

66

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8 August 2017

8

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8 August 2017

1627-1634

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The rotary mechanism of ATP synthase

8 August 2017

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

7 January 2021

Mechanisms of apoptosis

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

The mitochondrial death/life regulator in apoptosis and necrosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondria as the central control point of apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondria and apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondrial control of cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondria and neuronal survival

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Bcl-2 family proteins and mitochondria.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Cell biology. NO says yes to mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondria and degenerative disorders

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondrial abnormalities in Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Free radical theory of aging

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Role of mitochondrial dysfunction in Alzheimer's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondria, free radicals, and neurodegeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Oxidative stress and Alzheimer disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Oxidative stress in Alzheimer's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Advanced glycation endproducts in ageing and Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Oxidative damage is the earliest event in Alzheimer disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Sequence and organization of the human mitochondrial genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondrial DNA mutations in diseases of energy metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mitochondrial diseases in man and mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Alzheimer's disease is a synaptic failure

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Intracellular biology of Alzheimer's disease amyloid beta peptide

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Activation of caspase-8 in the Alzheimer's disease brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Both oxidative stress-dependent and independent effects of amyloid beta protein are detected by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction assay.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

beta-Amyloid peptide decreases membrane fluidity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Presenilin mutations and calcium signaling defects in the nervous and immune systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Alzheimer's disease: genes, proteins, and therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Enhanced vulnerability to apoptotic cell death in sporadic Alzheimerʼs disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Elevated levels of fragmented DNA nucleosomes in native and activated lymphocytes indicate an enhanced sensitivity to apoptosis in sporadic Alzheimer's disease. Specific differences to vascular dementia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Differential alterations in antioxidant capacity in cells from Alzheimer patients

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Oxidative damage to DNA in lymphocytes from AD patients.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Apoptosis. A cinderella caspase takes center stage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

Alpha-lipoic acid as a new treatment option for Alzheimer [corrected] type dementia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900534-3

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(03)00534-3

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release_fk5iozaktngltexjcpsfb2qvcy

8 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/fk5iozaktngltexjcpsfb2qvcy

mapped directly with Wikidata item

24 November 2022

based on heuristic

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