Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin. (Q40684984)

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15 December 2019

title

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin (English)

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15 December 2019

6

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15 December 2019

author name string

Jere E Meredith

1

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15 December 2019

Qian Wang

2

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15 December 2019

Thomas J Mitchell

3

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15 December 2019

Richard E Olson

4

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15 December 2019

Robert Zaczek

5

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15 December 2019

Dietmar Seiffert

7

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15 December 2019

publication date

1 December 2002

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Biochemical and Biophysical Research Communications

15 December 2019

published in

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15 December 2019

volume

299

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15 December 2019

issue

5

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15 December 2019

page(s)

744-750

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The presenilins in Alzheimer's disease--proteolysis holds the key.

15 December 2019

cites work

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

7 January 2021

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Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

7 January 2021

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Presenilin 1 interaction in the brain with a novel member of the Armadillo family

7 January 2021

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

7 January 2021

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Direct association of presenilin-1 with beta-catenin

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Signal transduction by the Wnt family of ligands

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Beta-catenin: a key mediator of Wnt signaling

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

7 January 2021

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The role of beta-catenin stability in mutant PS1-associated apoptosis

7 January 2021

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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

7 January 2021

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Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

7 January 2021

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Presenilin affects arm/beta-catenin localization and function in Drosophila.

7 January 2021

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Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

7 January 2021

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Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

7 January 2021

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Regulation of LEF-1/TCF transcription factors by Wnt and other signals

7 January 2021

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

7 January 2021

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Identification of c-MYC as a target of the APC pathway

7 January 2021

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

7 January 2021

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

7 January 2021

1 reference

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Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

7 January 2021

1 reference

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Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

7 January 2021

1 reference

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10.1016/S0006-291X(02)02747-X

7 January 2021

Identifiers

DOI

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15 December 2019

1 reference